Results 191 to 200 of about 1,239,617 (330)

Environmental and genetic influence on the rate and spectrum of spontaneous mutations in <i>Escherichia coli</i>. [PDF]

Microbiology (Reading)
Gifford DR, Bhattacharyya A, Geim A, Marshall E, Krašovec R, Knight CG.   +5 more
europepmc   +1 more source

Genetic mapping of a spontaneous short-grain mutation reveals a novel loss-of-function allele of SRS3 in rice

M. Montiel, Brijesh Angira, Jonathan K. Richards, Adam N. Famoso   +3 more
openalex   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Data from: Meiotic double strand DNA breaks and spontaneous mutation in Drosophila melanogaster

Melde, Rob, Daigle, Austin, Abraham, JoHanna, Sharp, Nathaniel   +3 more
  +5 more sources

Spontaneous mutations and mutational responses to penicillin treatment in the bacterial pathogen Streptococcus pneumoniae D39. [PDF]

Mar Life Sci Technol
Jiang W, Lin T, Pan J, Rivera CE, Tincher C, Wang Y, Zhang Y, Gao X, Wang Y, Tsui HT, Winkler ME, Lynch M, Long H.   +12 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Correction: Spontaneous mutations and mutational responses to penicillin treatment in the bacterial pathogen Streptococcus pneumoniae D39. [PDF]

Mar Life Sci Technol
Jiang W, Lin T, Pan J, Rivera CE, Tincher C, Wang Y, Zhang Y, Gao X, Wang Y, Tsui HT, Winkler ME, Lynch M, Long H.   +12 more
europepmc   +1 more source

Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types. [PDF]

Int J Mol Sci, 2020
Yeo JY, Koh DW, Yap P, Goh GR, Gan SK.
europepmc   +1 more source

A Spontaneous Mutation in tfo X Impairs Bioluminescence in Photobacterium kishitanii ANT ‐2200

Capucine Le Cam Ligier, Gwénola Simon, Charlotte Berthelier, Corinne Valette, Elisa Lefeuvre, Marc Garel, Laurie Casalot   +6 more
openalex   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source