Results 201 to 210 of about 1,239,617 (330)

Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred Caenorhabditis elegans mutation accumulation lines. [PDF]

Genetics
Crombie TA, Rajaei M, Saxena AS, Johnson LM, Saber S, Tanny RE, Ponciano JM, Andersen EC, Zhou J, Baer CF.   +9 more
europepmc   +1 more source

The effect of spontaneous mutations on CUP1 copy number and copper tolerance in Saccharomyces cerevisiae

Rohan Sohoni, Gottfried Schatz, Nathaniel P. Sharp   +2 more
openalex   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, EarlyView.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

A SPONTANEOUS MUTATION IN THE HOUSE MOUSE [PDF]

Proceedings of the National Academy of Sciences, 1929
openaire   +2 more sources

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Spontaneous mutation rate and spectrum are modulated by organismal fitness

Shuting Ding, Anjali Mahilkar, Yang Li, J Zhang   +3 more
openalex   +1 more source

Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects

SPONTANEOUS SINGLE-NUCLEOTIDE SUBSTITUTIONS AND MICROSATELLITE MUTATIONS HAVE DISTINCT DISTRIBUTIONS OF FITNESS EFFECTS Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects / Plavskin ...
Siegal, Mark L., Schwarz, Roland F., Janská, Libuše, Plavskin, Yevgeniy, Ziv, Naomi, Zhu, Yuan O., Hall, David W., Tranchina, Daniel   +7 more
core  

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Origin of spontaneous mutations in maize has been hiding in plain sight. [PDF]

Proc Natl Acad Sci U S A, 2019
Wessler SR.
europepmc   +1 more source

The murine Irs1 knockout model, generated by the spontaneous Irs1S57X mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis

Bruna Alves Fenerich, Jaqueline Cristina Fernandes, Cleide Lúcia Araújo Silva, João Agostinho Machado‐Neto, Fabı́ola Traina   +4 more
openalex   +1 more source