Results 281 to 290 of about 1,239,617 (330)

Spontaneous Mutation in Man

1975
Mutation is one of the basic phenomena of life. Without mutation, the gradual development of life from inorganic material would have been impossible, and the evolution of living beings from the first groups of molecules in which a primitive, information-carrying unit cooperated with an energy gaining device59 up to the present diversity of highly ...
F, Vogel, R, Rathenberg
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Spontaneous Mutations and Fidelogens

1993
The word “antimutagenesis” was first used by Novick and Szilard (51) to describe the lowering of the spontaneous mutation rate. Since then, Kada (26) has made antimutagenesis into a generic word to describe two types of events: the inactivation of mutagens or carcinogens before they can reach the DNA, and the events which can restore the DNA after ...
R C, von Borstel, U G, Hennig
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Craniomyeloschisis: A spontaneous mutation of the rat

Teratology, 1977
AbstractCraniomyeloschisis (proposed gene symbol cms) was a spontaneous mutation of the rat inherited as an autosomal recessive trait with complete penetrance. Homozygous offspring died at birth with failure of closure of the neural tube caudal to the midbrain. Neural crest derivatives were relatively normal.
W M, Layton, J M, Smith
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Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA

Nature, 1976
Strains of yeast carrying mutations in many of the steps in pathways repairing radiation-induced damage to DNA have enhanced spontaneous mutation rates. Most strains isolated because they have enhanced spontaneous mutation carry mutations in DNA repair systems.
P J, Hastings, S K, Quah, R C, von Borstel   +2 more
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BACTERIAL MUTATOR GENES AND THE CONTROL OF SPONTANEOUS MUTATION

Annual Review of Genetics, 1976
ISOLATION OF MUTATOR GENES 1 36 MUTATOR GENE PROPERTIES 137 The mutT Gene 137 The mutD Gene 139 The mutS Gene 140 The mutR Gene ..... 141 The mutL Gene 142 The uvrE (mutU) Gene 142 DNA Po/ymerases ... 143 Other .....•..• •.•.• •• • •..• •... 144 E.
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Spontaneous Mutation Rate in Drosophila

The American Naturalist, 1947
The frequency of spontaneously occurring lethal mutations in the X-chromosome of the Sw-b stock of D. melanogaster was found to be higher among spermatozoa of previously unmated males 16 to 17 days, and 32 to 33 days after emergence than among 1- to 2-day old males (Table 1).
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Are mutations spontaneous or directed

, 2007
Baake E. Are mutations spontaneous or directed. Nieuw Archief voor Wiskunde.
Baake, Ellen
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Mutation: Spontaneous Mutation in Germ Cells

1997
The most important feature of genes is their capacity to be reproduced identically from generation to generation. However, evolution would never have been possible if no change in genetic material had ever occurred. Since there is good evidence that all living beings on our planet have a common origin, genes as the carriers of genetic information must ...
Friedrich Vogel, Arno G. Motulsky
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Specificity of spontaneous mutations induced in mutA mutator cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004
Escherichia coli cells expressing the mutA allele of a glyV (glycine tRNA) gene express a strong mutator phenotype. The mutA allele differs from the wild type glyV gene by a base substitution in the anticodon such that the resulting tRNA misreads certain aspartate codons as glycine, resulting in random, low-level Asp-->Gly substitutions in proteins ...
Sergey, Balashov, M Zafri, Humayun
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Spontaneous Mutation as a Risk Factor

2015
From various estimates of the mutation rate per nucleotide per generation, centering around 1-2 x 10(-8) and the number of nucleotide pairs, 3 x 10(9) per genome, the number of new mutations in a human zygote is very large, in the order of 100. The mutation rate is an order of magnitude higher in males than females, due presumably to the greater number
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