Results 31 to 40 of about 6,976 (171)

Ring trial of 2nd generation RT‐QuIC diagnostic tests for sporadic CJD

Annals of Clinical and Translational Neurology, 2020
Objective Real‐time quaking‐induced conversion (RT‐QuIC) assays detect prion‐seeding activity in a variety of human biospecimens, including cerebrospinal fluid and olfactory mucosa swabs.
Christina D. Orrú, Bradley R. Groveman, Aaron Foutz, Matilde Bongianni, Franco Cardone, Neil McKenzie, Audrey Culeux, Anna Poleggi, Katarina Grznarova, Daniela Perra, Michele Fiorini, Xiaoqin Liu, Anna Ladogana, Marco Sbriccoli, Andrew G. Hughson, Stéphane Haïk, Alison J. Green, Michael D. Geschwind, Maurizio Pocchiari, Jiri G. Safar, Gianluigi Zanusso, Byron Caughey   +21 more
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CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]

, 2012
The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick, Albert C Ludolph, Hans A Kretzschmar, Ludolph, Albert C., Markus Otto, Kretzschmar, Hans A., Petra Steinacker, Stefan Lehnert, Ferger Boris, Patrick Oeckl, Otto, Markus, Ferger, Boris, Oeckl Patrick, Ludolph Albert C., Boris Ferger, Steinacker, Petra, Otto Markus, Lehnert Stefan, Steinacker Petra, Kretzschmar Hans A., Jesse, Sarah, Lehnert, Stefan, Sarah Jesse, Jesse Sarah   +23 more
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Public health concerns regarding sporadic Creutzfeldt–Jakob disease in China: a case series

Journal of International Medical Research, 2019
In this study, we report three cases of sporadic Creutzfeldt–Jakob disease in China, two confirmed cases and one probable case. The aim of this study was to enrich the data regarding clinical and epidemiological features of this disease and to provide ...
Ru-Yi Zhou, Yinzhu Zhou, Heng Zhang, Qingqing Hu, Jinjie Zhu, Jin Zhao, Shuilian Chen, Ruchun Liu, Weihong Hu, Xixing Zhang, Xianfa Xuan, Yuxue Liao, Tianmu Chen   +12 more
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Young-onset sporadic Creutzfeldt–Jakob disease with atypical phenotypic features: a case report

Journal of Medical Case Reports, 2019
Background Sporadic Creutzfeldt–Jakob disease, with a mean survival of 6 months, is duly considered among the most fatal neurological disorders. Rapidly progressive dementia with multi-axial involvement of the nervous system is the known presentation ...
Durjoy Lahiri, Srimant Pattnaik, Ashwani Bhat, Souvik Dubey, Atanu Biswas, Biman Kanti Roy   +5 more
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Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease [PDF]

, 2009
Several molecular subtypes of sporadic Creutzfeldt-Jakob disease have been identified and electroencephalogram and cerebrospinal fluid biomarkers have been reported to support clinical diagnosis but with variable utility according to subtype.
Summers, DM, Collins, S.J. (Steven), Brandel, J.P., Meissner, B, Meissner, B., Cras, P. (Patrick), Varges, D., Jansen, GH, Cras, Patrick, Pimentel, J, Brandel, J P, Smith, P., Taratuto, Ana Lia, van Duijn, Cornelia M., Begue, Christian, Summers, D. M., Summers, D.M., Jansen, G. H., Hewer, Ekkehard, Ladogana, Anna, Jansen, Gerard H, Will, Robert G., Schuur, M. (Maaike), Haik, S., Sanchez-Juan, P. (Pascual), Begue, C, Brandel, JP, Collins, S J, Heinemann, U., Haik, Stephane, Stokin, G B, Zerr, I., Schuur, M, Pimentel, Jose, Breithaupt, M., Taratuto, A, Sanchez-Juan, P, van Duijn, C., Stokin, GB, Breithaupt, Maren, Collins, SJ, Kallenberg, K., Sanchez-Juan, P., Collie, Donald A., Sanchez-Juan, Pascual, Hewer, E, Ladogana, A. (Anna), Schuur, M., Romero, C, Tikka-Kleemola, P. (Päivi), Cras, P., Schuur, Maaike, Romero, Carlos, Ladogana, A, Haik, S, Duijn, Cornelia, Stokin, G. B., Taratuto, A., Collie, D, Stokin, G.B., Brandel, J. P., Romero, C., Smith, P, Jansen, G H, Collie, D., Begue, C., Heinemann, U, Will, R G, Smith, Pete, Pocchiari, M., Collins, S. J., Pocchiari, Mauricio, Ladogana, A., Will, R. G., Will, RG, Meissner, Bettina, Summers, D M, Breithaupt, M, Jansen, G.H. (Gerard), Kallenberg, Kai, Hewer, E., Will, R.G., Cras, P, Zerr, I, Roberts, H., Jansen, Gerard H., Pocchiari, M, van Duijn, C, Pocchiari, M. (Maurizio), Varges, Daniel. A., Roberts, H, Brandel, Jean-Philippe, Kallenberg, K, Varges, D, Pimentel, J.   +94 more
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Applicability of long-term electroencephalography in pre-mortem diagnosis of Creutzfeldt–Jakob disease: A case report

SAGE Open Medical Case Reports, 2017
Creutzfeldt–Jakob disease accounts for more than 90% of all sporadic prion disease cases. The molecular MM2 genotype has been divided into cortical and thalamic subtypes based on structures involved and is characterized clinically by progressive dementia
Sanaz Attaripour Isfahani, Michelle Dougherty, Gediminas Peter Gliebus   +2 more
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Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]

, 2010
Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Meissner, Bettina, Bettina Meissner, Zerr, Inga, Redyk, Katharina, Christian Schmidt, Nico von Ahsen, Kretzschmar, Hans A., Lennart Krack, Schmidt, Christian, Roeber, Sigrun, von Ahsen, Nico, Katharina Redyk, Sigrun Roeber, Hans Kretzschmar, Inga Zerr, Krack, Lennart, Kretzschmar, Hans, Schmidt, Christian D., Krack, Lennart A., Ahsen, Nico von   +19 more
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Sporadic Creutzfeldt-Jakob disease with cerebellar ataxia at onset in the UK

, 2006
To determine the frequency, in the UK, of sporadic Creutzfeldt-Jakob Disease (sCJD) with a cerebellar ataxic onset, and to describe the clinical features of the ...
Will, R G, Heath, C A, Cooper, S A, Knight, R S G, Murray, K L   +4 more
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Efficient transmission and characterization of creutzfeldt-jakob disease strains in bank voles.

, 2006
Transmission of prions between species is limited by the "species barrier," which hampers a full characterization of human prion strains in the mouse model.
Bari Michele A. Di, Boyle, Aileen, Lipp Hans-Peter, Gabriele Vaccari, Maurizio Pocchiari, Cardone Franco, Sbriccoli Marco, Claudia Cartoni, Sbriccoli, Marco, Boyle Aileen, Dell'Omo, Giacomo, Nonno, Romolo, Di Bari, Michele A, Nonno Romolo, Franco Cardone, Galeno, Roberta, Marco Sbriccoli, Paola Fazzi, Vaccari Gabriele, Cartoni, Claudia, Cardone, Franco, Galeno Roberta, Loredana Ingrosso, Roberta Galeno, Fazzi, Paola, Lipp, Hans-Peter, Fazzi Paola, Michele A Di Bari, Ingrosso Loredana, Hans-Peter Lipp, Ingrosso, Loredana, Pocchiari, Maurizio, Umberto Agrimi, Pocchiari Maurizio, Vaccari, Gabriele, Agrimi, Umberto, Giacomo Dell'Omo, Moira Bruce, Aileen Boyle, Dell'Omo Giacomo, Agrimi Umberto, Bruce Moira, Bruce, Moira, Romolo Nonno, Cartoni Claudia   +44 more
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Movement Disorders in Prionopathies: A Systematic Review

Tremor and Other Hyperkinetic Movements, 2019
Background: Movement disorders are frequent features of prionopathies. However, their prevalence and onset remain poorly described. Methods: We performed a systematic review of case reports and case series of pathologically- and genetically confirmed ...
Federico Rodriguez-Porcel, Vinícius Boaratti Ciarlariello, Alok K. Dwivedi, Lilia Lovera, Gustavo Da Prat, Ricardo Lopez-Castellanos, Ritika Suri, Holly Laub, Ruth H. Walker, Orlando Barsottini, José Luiz Pedroso, Alberto J. Espay   +11 more
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