Results 51 to 60 of about 5,104,410 (171)

Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt–Jakob disease cohort

Brain Pathology, EarlyView.
Systematic neuropathological screening of 212 patients with Creutzfeldt–Jakob disease (55% women) identified chronic traumatic encephalopathy in three cases (1.4%), all men with a history of contact sports. These findings represent the first neuropathologically confirmed chronic traumatic encephalopathy cases reported in Spain.
Lluc Bertran, Iban Aldecoa, Arlène Sindikubwabo, Núria Vidal, Rafael Blesa, Mercè Martínez‐Corral, Carlos Nos, Verónica Santiago, Andrea González, Álex Iranzo, Christopher J. Nowinski, Ann C. McKee, Raquel Sánchez Valle, Laura Molina‐Porcel   +13 more
wiley   +1 more source

The presence of valine at residue 129 in human prion protein accelerates amyloid formation [PDF]

, 2005
The polymorphism at residue 129 of the human PRNP gene modulates disease susceptibility and the clinicopathological phenotypes in human transmissible spongiform encephalopathies.
Tahiri-Alaoui, Abdessamad, Gill, A, Shaw, Michael, Shaw, M, Baskakov, I, Breydo, L, James, W, Tahiri-Alaoui, A, Disterer, Petra, Gill, Andrew, Baskakov, Ilia, Breydo, Leonid, Disterer, P, James, William   +13 more
core   +1 more source

Changes in serum β‐synuclein precede blood biomarkers of Alzheimer pathology in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION There is a need for early, objective markers of Alzheimer's disease (AD)‐related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β‐synuclein is elevated in the blood of adults with DS. This study evaluates the positioning of these changes relative to changes in pathophysiological blood biomarkers ...
Alba Cervantes González, Alejandra O Morcillo‐Nieto, Sara Serrano, Bessy Benejam, Laura Videla, Isabel Barroeta, Susana Fernández, Laura del Hoyo Soriano, Aida S Hernandez, Lucía Maure‐Blesa, Lídia Vaqué‐Alcázar, Javier Arranz, Íñigo Rodríguez‐Baz, Mateus R Aranha, Danna Perlaza, Laia Lidón, Daniel Alcolea, Alexandre Bejanin, María Carmona‐Iragui, Juan Fortea, Alberto Lleó, Markus Otto, Patrick Oeckl, Olivia Belbin   +23 more
wiley   +1 more source

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) can be caused by autosomal‐dominant familial Alzheimer's disease (FAD) mutations in amyloid precursor protein (APP) or presenilin‐1 and 2, which form an enzyme substrate complex. KAT5 binds to the APP intracellular domain.
Greg A Cary, Jessica E. Young, Shannon E. Rose, Harald Frankowski, Heather Wilkins, Sai Sruthi Amirtha Ganesh, Julia Draper, Martin Darvas, Mark Bothwell, Suman Jayadev, Aquene N. Reid, Anna Greenwood, Allan I. Levey, Karina Leal, Gregory W. Carter, Jesse C. Wiley   +15 more
wiley   +1 more source

From Meat to Plant‐Based Products? The Enduring Impact of BSE on Beef Consumption

Agricultural Economics, Volume 57, Issue 4, July 2026.
ABSTRACT This study reassesses the impact of the historical BSE outbreak on EU diets, showing that consumption patterns shifted persistently even after policy actions eliminated the food safety risk. Utilizing advanced difference‐in‐differences techniques on 1980–2020 data, we demonstrate that while beef consumption exhibited a transient U‐shaped ...
Jader Velásquez, Shon Ferguson
wiley   +1 more source

Risk Ranking of Microbiological Hazards in Food (2015–2019)

Food Risk Assess Europe, Volume 4, Issue 3, July 2026.
Abstract Microbiological food safety risks arise from pathogens that can contaminate food at different points along the food chain. Exposure to these hazards can result in illnesses that can vary widely in severity and duration, depending on factors such as the specific pathogen involved, the amount of the pathogen ingested, and the susceptibility of ...
Ms Chloe Glennon, Lisa O’Connor, Kevin Burke, Lauren Russell, Shaun Smith, Declan Bolton, Theo de Waal, Patricia Garvey, Montserrat Gutierrez, Noel McCarthy, Lois O’Connor, Helen O’Shea, Geraldine Duffy   +12 more
wiley   +1 more source

HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone, Eleonora Busani, Roberto Chiesa   +2 more
wiley   +1 more source

White matter involvement in sporadic Creutzfeldt-Jakob disease [PDF]

, 2014
Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey matter, although the extent of white matter involvement has not been well described.
DeArmond, Stephen J, Vitali, Paolo, Papinutto, Nico, Mandelli, Maria Luisa, Henry, Roland G, Oehler, Abby, Geschwind, Michael D, Hess, Christopher P, Caverzasi, Eduardo, Lobach, Irina V, Miller, Bruce L, Bastianello, Stefano   +11 more
core   +2 more sources

Sporadic Creutzfeldt-Jakob disease: clinical observation

Анналы клинической и экспериментальной неврологии, 2017
Creutzfeldt-Jakob disease (CJD) is a form of human prion diseases,fatal neurodegenerative conditions. They can be etiologicallydivided into sporadic, hereditary and acquired forms.Conformational change of the normal (cellular) form of prionprotein (PrPc)
A. V. Peresedova, N. I. Stoida, V. V. Gnezdizky, R. N. Konоvаlоv, O. S. Kоrеpina, I. A. Zavalishin   +5 more
doaj   +1 more source

Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease

Communications Biology, 2021
Cheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease.
Lesley Cheng, Camelia Quek, Xia Li, Shayne A. Bellingham, Laura J. Ellett, Mitch Shambrook, Saima Zafar, Inga Zerr, Victoria A. Lawson, Andrew F. Hill   +9 more
doaj   +1 more source