Results 61 to 70 of about 5,281 (133)

Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
The amyloid cascade hypothesis places amyloid‐β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Evidence suggests that AD progresses in two phases: an early phase driven by Aβ aggregation and a later phase that progresses at least partly independently of Aβ.
Natalie Beschorner, Ying Xu, Mathias Jucker, Alejandro Ruiz‐Riquelme   +3 more
wiley   +1 more source

The new variant of the Creutzfeldt-Jakob disease accounts for no relative increase of the Creutzfeldt-Jakob disease mortality rate in the United Kingdom; this fits ill with the new variant being the consequence of consumption of food infected with the agent of Bovine Spongiform Encephalopathy

BMC Public Health, 2003
Background A new variant of Creutzfeldt-Jakob disease was described in the United Kingdom. It is often claimed that it is caused by consumption of food infected with the agent of bovine spongiform encephalopathy.
Hénaut Alain, Laprevotte Ivan
doaj   +1 more source

Prion disease diagnosis using subject-specific imaging biomarkers within a multi-kernel Gaussian process

NeuroImage: Clinical, 2019
Prion diseases are a group of rare neurodegenerative conditions characterised by a high rate of progression and highly heterogeneous phenotypes. Whilst the most common form of prion disease occurs sporadically (sporadic Creutzfeldt–Jakob disease, sCJD ...
Liane S. Canas, Carole H. Sudre, Enrico De Vita, Akin Nihat, Tze How Mok, Catherine F. Slattery, Ross W. Paterson, Alexander J.M. Foulkes, Harpreet Hyare, M. Jorge Cardoso, John Thornton, Jonathan M. Schott, Frederik Barkhof, John Collinge, Sébastien Ourselin, Simon Mead, Marc Modat   +16 more
doaj   +1 more source

Detection of Creutzfeldt-Jakob disease prions in skin: implications for healthcare

Genome Medicine, 2018
Editorial summary Evidence has recently been reported of prion seeding activity in skin tissue from patients with sporadic Creutzfeldt-Jakob disease (sCJD). This is relevant information for infection control measures during surgery.
Akin Nihat, Simon Mead
doaj   +1 more source

Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease

Emerging Infectious Diseases, 2012
We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein–transgenic mouse line and isolated distinct prion
Simon Nicot, Anna Bencsik, Eric Morignat, Nadine Mestre-Francés, Armand Perret-Liaudet, Thierry Baron   +5 more
doaj   +1 more source

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Emerging Infectious Diseases, 2018
A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported.
Daisy Bougard, Maxime Bélondrade, Charly Mayran, Lilian Bruyère-Ostells, Sylvain Lehmann, Chantal Fournier-Wirth, Richard S. Knight, Robert G. Will, Alison J.E. Green   +8 more
doaj   +1 more source

Chorea in Sporadic Creutzfeldt-Jakob Disease [PDF]

Journal of Movement Disorders, 2018
Ai Huey Tan, Tsun Haw Toh, Soon Chai Low, Si Lei Fong, Kah Kian Chong, Kee Wei Lee, Khean Jin Goh, Shen-Yang Lim   +7 more
doaj   +1 more source

Diffusion MR imaging in sporadic Creutzfeldt-Jakob disease

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014
Creutzfeldt-Jakob disease (CJD) is a rare dementing disease and is thought to caused by a prion. It is characterized by rapidly progressive dementia, ataxia, myoclonus, akinetic mutism and eventual death.
Burcak Cakir Pekoz, Ozlem Alkan, Semih Giray, senay Demir, Naime Altinkaya   +4 more
doaj  

When Thiamine Is Not the Answer: Sporadic Creutzfeldt-Jakob Disease Mimicking Wernicke's Encephalopathy. [PDF]

Cureus
Fagundo C, Xu C, Loreto R, Abugrara H.
europepmc   +1 more source

Neuropsychiatric symptoms in sporadic Creutzfeldt-Jakob disease. [PDF]

Brain
Zitser J, Forner S, Wong K, Chengshi J, Neuhaus J, Martindale J, Raudabaugh BJ, Benisano K, Goodman-O'Leary K, Metcalf S, Kim MO, Hakimi M, Allen IE, Miller BL, Rosen HJ, Rankin KP, Geschwind MD.   +16 more
europepmc   +1 more source