Results 61 to 70 of about 11,396 (179)

Atypical status of bovine spongiform encephalopathy in Poland: a molecular typing study [PDF]

, 2008
The aim of this study was to analyze molecular features of protease-resistant prion protein (PrPres) in Western blots of BSE cases diagnosed in Poland with respect to a possible atypical status.
Jacobs, J.G., Langeveld, J.P.M., Polak, M.P., Zmudzinski, J.F.   +3 more
core   +1 more source

Peripheral Signatures of Multidimensional Pathology in Symptomatic and Asymptomatic Creutzfeldt–Jakob Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Plasma biomarkers in CJD reveal multisystem involvement, with neuronal injury markers showing strong discriminative performance and vascular proteins indicating blood–brain barrier dysfunction. In asymptomatic PRNP mutation carriers, biomarker changes are minimal and emerge mainly near disease onset ABSTRACT Background Plasma markers of neuronal injury
Zhong‐Yun Chen, Min Chu, Yi‐Hao Wang, Rui Liu, Jing Zhang, Ai‐ling Yue, Hua Lu, Qian‐qian He, Jia‐hui Hou, Yu‐fei Chen, Hong Ye, Li‐Yong Wu   +11 more
wiley   +1 more source

Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993–2002

BMC Public Health, 2006
Background The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. Methods From data collected for surveillance purposes, we describe annual proportions of deaths due to ...
Jansen Gerard H, Lewis Victoria, Collins Steven, Sanchez-Juan Pascual, Van Duijn Cornelia, Alpérovitch Annick, Delasnerie-Lauprêtre Nicole, Brandel Jean-Philippe, Kretszchmar Hans A, Zerr Inga, Pocchiari Maurizio, Puopolo Maria, Mellina Vittorio, Stoeck Katharina, Almazán Javier, Glatzel Markus, de Pedro-Cuesta Jesús, Coulthart Michael B, Gelpi Ellen, Budka Herbert, Mitrova Eva   +20 more
doaj   +1 more source

Anti-N-methyl-D-Aspartate Receptor Encephalitis Mimicking Sporadic Creutzfeldt–Jakob Disease

Frontiers in Neurology, 2020
Objectives: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and sporadic Creutzfeldt–Jakob disease (sCJD) share similar clinical features. Here, we present two unusual cases of anti-NMDAR encephalitis who were misdiagnosed as sCJD at first ...
Jiao Liu, Liyan Chen, Jing Yang, Lan Wang, Huifang Shang, Xueping Chen   +5 more
doaj   +1 more source

Prion protein amyloidosis with divergent phenotype associated with two novel nonsense mutations in PRNP [PDF]

, 2009
Stop codon mutations in the gene encoding the prion protein (PRNP) are very rare and have thus far only been described in two patients with prion protein cerebral amyloid angiopathy (PrP-CAA).
Casper Jansen, Piero Parchi, Sabina Capellari, Ad J. Vermeij, Patrizia Corrado, Frank Baas, Rosaria Strammiello, Willem A. van Gool, John C. van Swieten, Annemieke J. M. Rozemuller, H Braak, V Campana, S Capellari, S Capellari, B Chesebro, U Finckh, P Gambetti, B Ghetti, B Ghetti, B Ghetti, B Ghetti, G Giaccone, F Gray, C Haass, J Hardy, SI Ikeda, JW Ironside, C Keohane, GR Mallucci, M Mohr, R Nitrini, S Notari, C Paquet, P Parchi, P Parchi, P Piccardo, T Revesz, F Tagliavini, J Tateishi, DR Thal, HV Vinters, S Vogelgesang, J Woulfe, M Yamada   +43 more
core   +3 more sources

Incidence of Creutzfeldt‐Jakob Disease in a Tertiary Care Referral Center in Mexico City

Alzheimer's &Dementia, Volume 21, Issue S6, December 2025.
Abstract Background Creutzfeldt‐Jakob disease (CJD) is a progressive, irreversible, and fatal disease associated with the misfolding of a protein in the central nervous system. Several surveillance programs emerged worldwide after the epidemic of the early 2000s. In Mexico, information about its epidemiology is scarce.
Ilse Murrieta Hernandez, Enrique Isaac Tetlalmatzi Azuara, Hector Tellez Lucero, Juan Carlos Lopez Hernandez, Enrique Piña Rosales, Brenda Dzul Garcia, Raul Medina Rioja   +6 more
wiley   +1 more source

A case of probable sporadic Creutzfeldt–Jakob disease

Family Medicine and Community Health, 2017
Creutzfeldt-Jakob Disease (CJD) is a fatal neurodegenerative brain disease. The author describes a case presented to primary care clinic whereby neuropsychiatric symptoms were the patient’s initial presentation which later manifested with declining ...
Norita Hussein
doaj   +1 more source

Selective vulnerability to atrophy in sporadic Creutzfeldt‐Jakob disease

Annals of Clinical and Translational Neurology, 2021
Objective Identification of brain regions susceptible to quantifiable atrophy in sporadic Creutzfeldt‐Jakob disease (sCJD) should allow for improved understanding of disease pathophysiology and development of structural biomarkers that might be useful in
Kyan Younes, Julio C. Rojas, Amy Wolf, Goh M. Sheng‐Yang, Matteo Paoletti, Gianina Toller, Eduardo Caverzasi, Maria Luisa Mandelli, Ignacio Illán‐Gala, Joel H. Kramer, Yann Cobigo, Bruce L. Miller, Howard J. Rosen, Michael D. Geschwind   +13 more
doaj   +1 more source

Prodromal Sleep Disturbances and Polysomnographic Findings in Patients With Creutzfeldt–Jakob Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This study investigates the sleep‐related manifestations of Creutzfeldt–Jakob disease (CJD) by analyzing electroencephalography (EEG) and polysomnography (PSG) findings in a cohort of seven patients diagnosed between 2013 and 2023. Although only three patients initially reported sleep‐related complaints, comprehensive assessments revealed that all ...
Ezgi Demirel, Gul Yalcin‐Cakmakli, Ezgi Yetim, Serap Saygi, Fadime Irsel Tezer   +4 more
wiley   +1 more source

Sporadic Creutzfeldt-Jakob disease: Clinical, pathological and molecular study [PDF]

Revista Ciencias de la Salud, 2008
phalopathiesare neurodegenerative diseasescaused by abnormal accumulation of pathogenicisoform the prion protein, which induces theformation of conglomerates protein resistantto degradation.
Victoria Eugenia Villegas, Fernando Velandia, Cesar Payán   +2 more
doaj