Results 81 to 90 of about 11,396 (179)

Fatal familial insomnia that begins with unconsciousness: A case report

Sleep Research, Volume 3, Issue 1, Page 71-77, March 2026.
Wenyan Liu, Xinyue Xing, Xiaoming Wang, Xuqian Liu, Mingyue Liu, Wei Shang, Zhaohong Xie   +6 more
wiley   +1 more source

Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
The amyloid cascade hypothesis places amyloid‐β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Evidence suggests that AD progresses in two phases: an early phase driven by Aβ aggregation and a later phase that progresses at least partly independently of Aβ.
Natalie Beschorner, Ying Xu, Mathias Jucker, Alejandro Ruiz‐Riquelme   +3 more
wiley   +1 more source

Human α2β1HI CD133+VE epithelial prostate stem cells express low levels of active androgen receptor [PDF]

, 2012
Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated.
A Birgersdotter, Anastasia C. Hepburn, AS Goldstein, AT Collins, AT Collins, C Cai, C Lin, CD Chen, CJ Shepherd, Claudia A. Ryan-Munden, CM van der Loos, Craig N. Robson, D Corbeil, DA Lawson, Deepali Pal, DJ Vander Griend, DM Owens, DT Ross, G Attard, G Buchanan, GD Richardson, GR Cunha, H Bonkhoff, H Bonkhoff, Hing Y. Leung, IV Litvinov, J Perez-Losada, J Yu, JA Kemppainen, JK Blackwood, Kelly Coffey, KG Leong, KM Bae, L Patrawala, Laura Wilson, LE Lamb, MC Haffner, N Platet, NT Gaisa, R Heer, R Heer, Rakesh Heer, S Kolli, S Mousses, SO Lee, Stuart C. Williamson, VK Rajasekhar, X Wang, Yao Liang Tang   +48 more
core   +4 more sources

Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer, Lea T. Grinberg, Jared T. Ahrendsen, Thomas G. Beach, Kevin F. Bieniek, Rudolph J. Castellani, Rati Chkheidze, Inma Cobos, Mark Cohen, John F. Crary, Dennis W. Dickson, Brittany N. Dugger, Sara R. Dunlop, Kurt Farrell, Bernardino Ghetti, Mohammad Haeri, William Harrison, Elizabeth Head, Annie Hiniker, Eric J. Huang, Anita Huttner, Pouya Jamshidi, Alifiya Kapasi, C. Dirk Keene, Julia Kofler, Caitlin S. Latimer, Ann C. McKee, Karin Mente, Michael B. Miller, Thomas J. Montine, Meaghan Morris, Melissa E. Murray, Peter T. Nelson, Kathy L. Newell, Richard J. Perrin, Biswarathan Ramani, R. Ross Reichard, Subhojit Roy, Johannes C. M. Schlachetzki, William W. Seeley, Geidy E. Serrano, Salvatore Spina, Andrew F. Teich, Shih‐Hsiu J. Wang, Thomas Wisniewski, Edward B. Lee   +45 more
wiley   +1 more source

Sporadic Creutzfeldt–Jakob Disease Appears to Be Sporadic Fatal Insomnia: A Case Report and Review of the Literature

Nature and Science of Sleep, 2021
Qingqing Sun, Pingping Shen, Jiayi Tang, Hongmei Meng, Jiachun Feng, Zan Wang, Li Cui Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Zan Wang; Li Cui ...
Sun Q, Shen P, Tang J, Meng H, Feng J, Wang Z, Cui L   +6 more
doaj  

Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease [PDF]

, 2009
Several molecular subtypes of sporadic Creutzfeldt-Jakob disease have been identified and electroencephalogram and cerebrospinal fluid biomarkers have been reported to support clinical diagnosis but with variable utility according to subtype.
I. Zerr, K. Kallenberg, D. M. Summers, C. Romero, A. Taratuto, U. Heinemann, M. Breithaupt, D. Varges, B. Meissner, A. Ladogana, M. Schuur, S. Haik, S. J. Collins, G. H. Jansen, G. B. Stokin, J. Pimentel, E. Hewer, D. Collie, P. Smith, H. Roberts, J. P. Brandel, C. van Duijn, M. Pocchiari, C. Begue, P. Cras, R. G. Will, P. Sanchez-Juan, Castellani, Chang, Collie, Fujita, Gambetti, Geschwind, Geschwind, Green, Haik, Heinemann, Hoshino, Jacobi, Josephs, Kallenberg, Krasnianski, Krasnianski, Masters, Meissner, Parchi, Parchi, Poser, Sanchez-Juan, Sanchez-Juan, Satoh, Seipelt, Tschampa, Tschampa, Vernino, Young, Zerr, Zerr   +57 more
core   +9 more sources

Evolution of Diffusion-Weighted Magnetic Resonance Imaging Signal Abnormality in Sporadic Creutzfeldt-Jakob Disease, With Histopathological Correlation [PDF]

, 2015
IMPORTANCE: Prion diseases represent the archetype of brain diseases caused by protein misfolding, with the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive dementia.
Brandner, S, Carswell, CJ, Collinge, J, Eisenmenger, L, Hyare, H, Jäger, HR, Mead, S, Porter, MC, Rudge, P, Thompson, A   +9 more
core   +1 more source

Chameleonic Nature of Aβ: Implications for Alzheimer's and Other Amyloid Diseases

BioEssays, Volume 47, Issue 9, September 2025.
The energy landscape of Aβ reveals its flexible, “chameleon‐like” behavior, enabling diverse structures from disordered to β‐rich forms. This polymorphism facilitates aggregation, contributing to Alzheimer's disease progression, while the flat landscape also allows disaggregation, potentially slowing disease progression compared to prion proteins with ...
Birgit Strodel
wiley   +1 more source

Transmission of CJD from nasal brushings but not spinal fluid or RT‐QuIC product

Annals of Clinical and Translational Neurology, 2020
Objective The detection of prion seeding activity in CSF and olfactory mucosal brushings using real‐time quaking‐induced conversion assays allows highly accurate clinical diagnosis of sporadic Creutzfeldt–Jakob disease.
Gregory J. Raymond, Brent Race, Christina D. Orrú, Lynne D. Raymond, Matilde Bongianni, Michele Fiorini, Bradley R. Groveman, Sergio Ferrari, Luca Sacchetto, Andrew G. Hughson, Salvatore Monaco, Maurizio Pocchiari, Gianluigi Zanusso, Byron Caughey   +13 more
doaj   +1 more source

Increase of Plasma Biomarkers in Friedreich's Ataxia: Potential Insights into Disease Pathology

Movement Disorders, Volume 40, Issue 9, Page 1863-1873, September 2025.
Abstract Background Therapeutic interventions in Friedreich's ataxia (FRDA) are progressing into clinical trials, and the need for robust and easily accessible biomarkers has arisen. Objective This study aimed to consolidate preliminary findings of changes in the levels of neurofilament light (NfL), glial fibrillary acidic protein (GFAP), Tau, and ...
Christian Rummey, Gilbert Thomas‐Black, Hector Garcia‐Moreno, David R. Lynch, Rosella Abeti, Huseyin Arisoy, Amanda Heslegrave, Henrik Zetterberg, Paola Giunti, the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS), Jörg Bernhard Schulz, Kathrin Reetz, Claire Didszun, Thomas Klockgether, Ilaria Giordano, Massimo Pandolfo, Chantal Depondt, Myriam Rai, Sylvia Boesch, Wolfgang Nachbauer, Andreas Eigentler, Elisabetta Indelicato, Paola Giunti, Michael Parkinson, Katarina Manso, Gilbert Thomas‐Black, Hector Garcia‐Moreno, Nita Solanky, Rosella Abeti, James Polke, Robin Labrum, Francisco Rodríguez de Rivera Garrido, Javier Mascias, Sara Sánchez Velasco, Sergio Secades García, Caterina Mariotti, Lorenzo Nanetti, Anna Castaldo, Alessia Mongelli, Mario Fichera, Thomas Klopstock, Ivan Karin, Claudia Stendel, Florentine Radelfahr, Alexandra Durr, Perrine Charles, Claire Ewenczyk, Jennifer Just, Georgios Koutsis, Richard Walsh, Enrico Bertini   +50 more
wiley   +1 more source