Results 31 to 40 of about 16,859 (216)

Sporadic Creutzfeldt–Jakob disease is associated with reorganization of metabolic connectivity in a pathological brain network

European Journal of Neurology, 2022
Although sporadic Creutzfeldt–Jakob disease (sCJD) is a rare cause of dementia, it is critical to understand its functional networks as the prion protein spread throughout the brain may share similar mechanisms with other more common neurodegenerative ...
T. Rus, J. Mlakar, L. Lezaic, A. Vo, Nha Nguyen, Chris C. Tang, M. Fiorini, E. Prieto, Gloria Martí-Andrés, J. Arbizu, D. Eidelberg, M. Trost   +11 more
semanticscholar   +1 more source

Sporadic MM-1 Type Creutzfeldt-Jakob Disease With Hemiballic Presentation and No Cognitive Impairment Until Death: How New NCJDRSU Diagnostic Criteria May Allow Early Diagnosis

Frontiers in Neurology, 2018
Sporadic Creutzfeldt-Jakob disease is the most common human prion disorder. Although associated with heterogeneous clinical phenotypes, its distinctive feature is the presence of a rapidly progressive multidomain cognitive impairment.
Lorenzo Saraceno, Vito A. G. Ricigliano, Michele Cavalli, Alessandro Cagol, Giovanna Bosco, Fabio Moda, Paola Caroppo, Giovanni Meola, Giovanni Meola   +8 more
doaj   +1 more source

Autoantibodies in Sporadic Creutzfeldt-Jakob Disease [PDF]

JAMA Neurology, 2013
The diagnosis of autoimmune and neurodegenerative conditions can be unclear. Treatments such as removing the associated tumor, if present, and immunosuppression can halt or often reverse the progression of autoimmune conditions, but there is no curative treatment for neurodegenerative conditions.
Angus-Leppan, H, Rudge, P, Mead, S, Collinge, J, Vincent, A   +4 more
openaire   +2 more sources

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study.

Lancet Neurology, 2020
BACKGROUND Human prion diseases are rare and usually rapidly fatal neurodegenerative disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD).
E. Jones, H. Hummerich, Emmanuelle Viré, J. Uphill, A. Dimitriadis, H. Speedy, T. Campbell, P. Norsworthy, L. Quinn, J. Whitfield, J. Linehan, Z. Jaunmuktane, S. Brandner, P. Jat, Akın Nihat, T. Mok, Parvin S. Ahmed, S. Collins, C. Stehmann, S. Sarros, G. Kovacs, M. Geschwind, Aili Golubjatnikov, K. Frontzek, H. Budka, A. Aguzzi, Hata Karamujić‐Čomić, S. Lee, C. Ibrahim-Verbaas, C. Duijn, B. Sikorska, E. Golańska, P. Liberski, M. Calero, Olga Calero, P. Sánchez-Juan, Antonio Salas, F. Martinón-Torres, E. Bouaziz-Amar, S. Haïk, J. Laplanche, J. Brandel, P. Amouyel, J. Lambert, Piero Parchi, A. Bartoletti-Stella, S. Capellari, A. Poleggi, A. Ladogana, M. Pocchiari, S. Aneli, G. Matullo, R. Knight, Saima Zafar, I. Zerr, S. Booth, M. Coulthart, G. Jansen, Katie Glisic, Janis E. Blevins, P. Gambetti, J. Safar, B. Appleby, J. Collinge, S. Mead   +64 more
semanticscholar   +1 more source

Diagnostic accuracy of cerebrospinal fluid biomarkers for the differential diagnosis of sporadic Creutzfeldt–Jakob disease: a (network) meta‐analysis

European Journal of Neurology, 2022
There are no systematic reviews of cerebrospinal fluid and blood biomarkers for sporadic Creutzfeldt–Jakob disease (sCJD) in specialized care settings that compare diagnostic accuracies in a network meta‐analysis (NMA).
N. Rübsamen, S. Pape, Stefan Konigorski, A. Zapf, G. Rücker, A. Karch   +5 more
semanticscholar   +1 more source

Epidemiological and Clinical Characteristics of Sporadic Creutzfeldt–Jakob Disease: A Retrospective Study in Eastern China

Frontiers in Neurology, 2021
Objective: We aimed to characterize the epidemiological and clinical characteristics of sporadic Creutzfeldt–Jakob disease (sCJD) in eastern China in this retrospective study.
S. Feng, Xinjin Zhao, Xue-ying Zhou, Xiang Ye, Xiao-lin Yu, Wei Jiang, Yu Deng, Shengnian Zhou, Lin Ma, Pei-yan Shan, Guoyu Zhou   +10 more
semanticscholar   +1 more source

Classification of sporadic Creutzfeldt-Jakob disease revisited [PDF]

Brain, 2006
The sporadic form of Creutzfeldt-Jakob disease (sCJD) has been classified on the basis of the molecular mass of the protease-resistant scrapie prion protein (PrP(Sc)), which can be type 1 or type 2, and the genotype at the methionine (M)/valine (V) polymorphic codon 129, which can be MM, MV or VV.
Cali I., Castellani R., Yuan J., Al Shekhlee A., Cohen M. L., Xiao X., Moleres F. J., PARCHI, PIERO, Zou W. Q., Gambetti P.   +9 more
openaire   +2 more sources

Interlaboratory validation of cerebrospinal fluid α‐synuclein quantification in the diagnosis of sporadic Creutzfeldt‐Jakob disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Cerebrospinal fluid α‐synuclein level is increased in sporadic Creutzfeldt‐Jakob disease cases. However, the clinical value of this biomarker remains to be established.
Niels Kruse, Amanda Heslegrave, Vandana Gupta, Martha Foiani, Anna Villar‐Piqué, Matthias Schmitz, Sylvain Lehmann, Charlotte Teunissen, Kaj Blennow, Henrik Zetterberg, Brit Mollenhauer, Inga Zerr, Franc Llorens   +12 more
doaj   +1 more source

Creutzfeldt–Jakob disease: A case report and differential diagnoses

Clinical Case Reports, 2022
Although sporadic Creutzfeldt–Jakob disease is a rare neurodegenerative disease and often difficult to diagnose at the earliest onset, meticulous clinical examination, electroencephalography, and neuroimaging findings will help in diagnosis.
Akash Raut, Anjila Thapa, Ashish Shrestha, Kamal Saud, Reema Rajbhandari, Shailendra Katwal   +5 more
doaj   +1 more source

Ring trial of 2nd generation RT‐QuIC diagnostic tests for sporadic CJD

Annals of Clinical and Translational Neurology, 2020
Objective Real‐time quaking‐induced conversion (RT‐QuIC) assays detect prion‐seeding activity in a variety of human biospecimens, including cerebrospinal fluid and olfactory mucosa swabs.
Christina D. Orrú, Bradley R. Groveman, Aaron Foutz, Matilde Bongianni, Franco Cardone, Neil McKenzie, Audrey Culeux, Anna Poleggi, Katarina Grznarova, Daniela Perra, Michele Fiorini, Xiaoqin Liu, Anna Ladogana, Marco Sbriccoli, Andrew G. Hughson, Stéphane Haïk, Alison J. Green, Michael D. Geschwind, Maurizio Pocchiari, Jiri G. Safar, Gianluigi Zanusso, Byron Caughey   +21 more
doaj   +1 more source