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Implications of imaging malaria sporozoites
Trends in Parasitology, 2008The sporozoites of Plasmodium parasites undergo several transmigrations before their establishment in the hepatocytes of a vertebrate host. Techniques that illustrate parasite intra-vital migration and their interaction with host cells will advance the understanding of parasite biology. In a recent publication, Amino et al. provided a detailed protocol
Qijun, Chen, Heng, Wang
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Multistep adhesion of Plasmodium sporozoites
The FASEB Journal, 2010Adhesion of eukaryotic cells is a complex process during which interactions between extracellular ligands and cellular receptors on the plasma membrane modulate the organization of the cytoskeleton. Pathogens particularly rely often on adhesion to tissues or host cells in order to establish an infection.
Hegge, S. +6 more
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Sinusoidal Sporozoite SPECTacle
Science, 2004MICROBIOLOGY During malaria infection, sporozoites injected from the salivary gland of the biting mosquito must migrate to the hepatocytes of the victim's liver to multiply and develop. To access the hepatocytes, the sporozoites must pass from the circulation across a layer of liver sinusoidal ...
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Cell invasion by Theileria sporozoites
Trends in Parasitology, 2003Abstract Theileria are intracellular protozoan parasites of veterinary importance, and their impact on livestock production in many developing countries has a significant negative effect on the quality of human life. Host cell invasion is a crucial aspect of Theileria biology.
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Whole-Sporozoite Malaria Vaccines
2017Whole-sporozoite administration is the sole immunization strategy that has been shown to elicit sterile immunity against malaria. Sporozoite-based immunization aims at eliciting potent pre-erythrocytic immune responses whilst preventing the appearance and progression of the symptomatic blood stages of infection.
António M. Mendes +5 more
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