Results 191 to 200 of about 471,278 (247)

Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats.

Regulatory toxicology and pharmacology : RTP, 2019
Citrus sinensis contains glycoside hesperetin-7-rhamnoglucoside (hesperidin) which harbor an array of therapeutic potentials including antioxidant, anticancer, and anti-inflammatory.
Yongsheng Li, A. Kandhare, A. Mukherjee, S. Bodhankar   +3 more
semanticscholar   +1 more source

Behavioral heterogeneity in Sprague-Dawley rats

Physiology & Behavior, 1992
Because of consistent individual differences in animal behavior, it is often difficult to interpret experimental data. We therefore attempted to rank Sprague Dawley rats by a hierarchical ascendant clustering technique using data from avoidance conditioning and open-field testing (scores of exploratory activity before, during, and after an ...
M, Curé, J P, Rolinat
openaire   +2 more sources

Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague-Dawley rats.

Food and Chemical Toxicology, 2019
Chronic exposure to cadmium (Cd) causes remarkable damage to the liver and gastrointestinal tract. Previous studies have revealed that chlorogenic acid (CGA) could improve the intestinal barrier integrity for weaned rats.
Yanwen Xue, Fang Huang, Rongxue Tang, Qingsheng Fan, Bing Zhang, Z. Xu, Xiaoming Sun, Z. Ruan   +7 more
semanticscholar   +1 more source

Respiratory tract lung geometry and dosimetry model for male Sprague-Dawley rats

Inhalation Toxicology, 2014
F. J. Miller, B. Asgharian, J. Schroeter, Owen Price, R. Corley, D. Einstein, R. Jacob, T. Cox, S. Kabilan, T. Bentley   +9 more
semanticscholar   +3 more sources

Spontaneous Hibernomas in Sprague-Dawley Rats

Toxicologic Pathology, 2009
Hibernomas are rare neoplasms originating in brown adipose tissue of humans and other animal species, including laboratory animals. Background incidence values for these tumors in all common strains of laboratory rats are generally accepted as being <0.1%.
Richard H, Bruner, Meliton N, Novilla, Catherine A, Picut, Jeannie B, Kirkpatrick, Thomas P, O'Neill, Kathryn L, Scully, Wade B, Lawrence, Dawn G, Goodman, Brett H, Saladino, David G, Peters, George A, Parker   +10 more
openaire   +2 more sources

Postirradiation Sarcomas in Sprague-Dawley Rats

Radiation Research, 1998
A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with 60Co gamma rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in
P T, Tinkey, T M, Lembo, G R, Evans, J H, Cundiff, K N, Gray, R E, Price   +5 more
openaire   +2 more sources

Prostate cancer in a Sprague‐Dawley rat

The Prostate, 1985
AbstractAn adenocarcinoma of the prostate gland developed in one rat of the Lobund Sprague‐Dawley (S‐D) strain, following treatments with testosterone propionate in silastic membranes. The transplanted cells (PA‐SD1) developed local tumors, metastasized through lymphatic channels to the lungs, and induced osteolytic lesions when deposited adjacent to ...
M, Pollard, P H, Luckert
openaire   +2 more sources

Respiration in Sprague-Dawley Rats During Pregnancy

Inhalation Toxicology, 2006
Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their widespread use as an animal model. Since respiration will affect the pharmacokinetics of volatile compounds and ultimately the dose to the fetus, we conducted a study to evaluate respiration in rats ...
Teresa L, Leavens, Carl U, Parkinson, R Arden, James, Dennis, House, Barbara, Elswick, David C, Dorman   +5 more
openaire   +2 more sources

Acute and 13 weeks subchronic toxicological evaluation of naringin in Sprague-Dawley rats.

Food and Chemical Toxicology, 2013
Peibo Li, Sheng-long Wang, X. Guan, B. Liu, Yonggang Wang, Ke Xu, W. Peng, Weiwei Su, Ke-jian Zhang   +8 more
semanticscholar   +3 more sources

Olanzapine Induced Thrombocythemia in Sprague‐Dawley Rats

Drug and Chemical Toxicology, 2004
Olanzapine was administered orally (20 mg/kg/day) in Sprague-Dawley rats. Forty-eight male Sprague-Dawley rats were divided into eight groups of six animals each. Four groups of animals received olanzapine for 7, 14, 21 and 48 days. There were no significant changes in hematological, clinical biochemistry parameters and superoxide dismutase activity in
Manoj, Patel, Cherian, Bapu, Harish, Padh, Manish, Nivsarkar   +3 more
openaire   +2 more sources