Results 321 to 330 of about 334,934 (359)
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Spontaneous leukaemia in a sprague-dawley rat
Experientia, 1962Description d'un cas de chloroleucemie myeloide chez un rat de souche Sprague-Dawley, presentant quelques modifications peu communes des tubes renaux.
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Carcinogenicity of nitrosoazetidine and tetradeuteronitrosoazetidine in sprague-dawley rats
Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1977Nitrosoazetidine was fed to rats in drinking water at three different concentrations. At 2 mmol (10 mmol total dose) all of the rats died with hepatocellular carcinomas by the 62nd week. This was a greater response than to an equivalent dose of nitrosopyrrolidine. At 0.67 mmol, 6 of 21 rats developed liver tumors, and at 0.17 millimolar 2 of 30 animals
W, Lijinsky, H W, Taylor
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The nephrotoxic potential of styrene in sprague-dawley rats
Toxicology Letters, 1983Pre-fasted (16 h) Sprague-Dawley male rats were treated i.p. with 0, 0.2, 0.4, 0.8 and 1.2 g/kg of styrene in corn oil. Renal functions were assessed at 0-24, 24-48 and 48-72 h after the exposure. Urinary creatinine was decreased at 0.8 g/kg of styrene during 0-24 h after the treatment compared to control, whereas such a decrease was noticed in 1.2 g ...
S, Chakrabarti, J, Brodeur
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Olanzapine Induced Thrombocythemia in Sprague‐Dawley Rats
Drug and Chemical Toxicology, 2004Olanzapine was administered orally (20 mg/kg/day) in Sprague-Dawley rats. Forty-eight male Sprague-Dawley rats were divided into eight groups of six animals each. Four groups of animals received olanzapine for 7, 14, 21 and 48 days. There were no significant changes in hematological, clinical biochemistry parameters and superoxide dismutase activity in
Manoj, Patel +3 more
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Carcinogenicity of 4-chloronitrosopiperidine in Sprague-Dawley rats
Zeitschrift f�r Krebsforschung und Klinische Onkologie, 19784-Chloronitrosopiperidine was administered to a group of 15 male Sprague-Dawley rats as a 0.005% solution in drinking water for 27 weeks. Of the 15 animals, 12 died with tumors induced by the treatment, half of them by the 41 st week; all 15 were dead at 58 weeks.
W, Lijinsky, H W, Taylor
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Carcinogenicity of 8-nitroquinoline in Sprague—Dawley rats
Cancer Letters, 19788-Nitroquinoline was added to the semisynthetic diet of outbred Sprague-Dawley rats for 48 weeks. Squamous cell carcinomas of the upper digestive tract (tongue and esophagus), but especially of the forestomach, occurred among the higher concentration groups.
M, Takahashi +5 more
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Spontaneous brain tumours in Sprague-Dawley rats
Food and Chemical Toxicology, 1986Data were collected over a 5-yr period on brain tumours occurring spontaneously among Sprague-Dawley-derived rats in the HRC laboratories. Gliomas, like meningiomas, tended to occur more among males than in females, and in general appeared to be lesions of older rats. Astrocytic tumours of rats were less differentiated than those in man.
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Spontaneous neoplasms in aged sprague-dawley rats
Archives of Toxicology, 1992Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid ...
M, Chandra, M G, Riley, D E, Johnson
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Developmental Toxicity of Thiodiglycol in Sprague-Dawley Rats
International Journal of Toxicology, 2007Thiodiglycol (TG), a hydrolysis product of sulfur mustard (HD), is a potential contaminant of soil and water at certain military sites. To establish developmental toxicity criteria for TG, an oral developmental toxicity study was conducted in Sprague-Dawley rats.
John T, Houpt +4 more
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Disposition of butadiene epoxides in Sprague-Dawley rats
Chemico-Biological Interactions, 19971,2-Epoxybutene (BMO) and diepoxybutane (BDE) are metabolic products of 1,3-butadiene in rodents. Both BMO and BDE are suspect in the development of tumors in rats and mice. To understand the distribution and elimination of these compounds in the absence of the rate-limiting production from butadiene, the pharmacokinetics of BMO and BDE in blood were ...
J L, Valentine +5 more
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