Results 41 to 50 of about 306,568 (267)

Effects of Amphetamine on Striatal Dopamine Release, Open-Field Activity, and Play in Fischer 344 and Sprague–Dawley Rats

, 2015
Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning.
Akopian, Garnik, Eck, Samantha R., McDowell, Lana S., Siviy, Stephen M., Turano, Alexandra, Walsh, John P.   +5 more
core   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Magnetically Guided Mechanoactive Mineralization Scaffolds for Enhanced Bone Regeneration

Advanced Functional Materials, EarlyView.
A 3D‐printed ‘rebar‐concrete’ inspired scaffold (PGS‐P@MGel) synergizes spontaneous biomineralization with magneto‐mechanical stimulation through PDA@Fe3O4‐embedded hydrogel. This dual biointerface activates Piezo1/β‐catenin/YAP mechanotransduction axis, enhancing BMSCs osteogenesis and angiogenesis simultaneously.
Xuran Guo, Zaijin Tao, Zhenzhen Dai, Yinghua Gao, Chengzhen Chu, Cunyi Fan, Shen Liu, Xin Ma, Fangchun Jin, Zhengwei You, Jia Jiang   +10 more
wiley   +1 more source

Radiative torques of irregular grains: Describing the alignment of a grain ensemble [PDF]

, 2018
The radiative torque (RAT) mechanism is the most promising way of explaining observed polarization arising from aligned grains. We explore the efficiency of the grain alignment by an anisotropic radiation flow for an extensive ensemble of grain shapes. We calculate the distribution of the ratios of the amplitudes of the two major components of the RATs,
arxiv   +1 more source

Developmental toxic effects of ethylbenzene or toluene alone and in combination with butyl acetate in rats after inhalation exposure [PDF]

, 2007
First, the developmental toxic potential of n-butyl acetate (BA) was examined in Sprague-Dawley rats following whole body inhalation exposure, 6 h day-1, from day 6 to 20 of gestation, at concentrations of 0, 500, 1000, 2000 and 3000 ppm.
Bourges-Abella, Nathalie, Gallissot, Frédéric, Muller, Samuel, Sabaté, Jean-Philippe, Saillenfait, Anne-Marie   +4 more
core  

Black Cumin Seed Oil Increase Leucocyte and CD4Thelper Number in Sprague-dawley Rats Induced with Dimethylbenzanthracene [PDF]

, 2019
Cigarette smoke contains 7, 12 dimethylbenzanthracene (DMBA). Metabolic of DMBA is immunosuppressive. Black cumin seed oil (BCSO) is an immunomodulation.
Akrom, A. (Akrom), Hidayati, T. (Titiek), Indrayanti, I. (Indrayanti), Sagiran, S. (Sagiran)   +3 more
core   +3 more sources

Development of Substrate‐Independent Antifouling and Bactericidal Surfaces Using Visible Light Cross‐Linked Hydrogel Coatings for Biomedical Applications

Advanced Healthcare Materials, EarlyView.
A new antifouling, antithrombogenic, and bactericidal hydrogel coating method is developed for implantable medical devices. The hydrogel coating can be easily formed by visible‐light crosslinking and is universally applicable to all substrates, ranging from polymers to metals.
Soonjong Roh, Se Youn Jang, Youngmee Jung, Kangwon Lee, Jin Yoo   +4 more
wiley   +1 more source

Energy Balance in Cell Phone Radiofrequency Radiation Exposed Mice and Rats [PDF]

arXiv, 2019
The National Toxicology Program exposed mice and rats to cell phone radiofrequency radiation. They observer cancers in male rats but not in male mice and different increases in body temperature between mice and rats using identical frequency and intensity exposures.
arxiv  

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source