Results 91 to 100 of about 271,794 (297)
Lava Geochemistry as a Probe into Crustal Formation at the East Pacific Rise [PDF]
Oceanography, 2012 Basalt lavas comprise the greatest volume of volcanic rocks on Earth, and most of them erupt along the world's mid-ocean ridges (MORs). These MOR basalts (MORBs) are generally thought to be relatively homogeneous in composition over large segments of the
Michael R. Perfit +8 more
doaj
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Active Long-Lived Faults Emerging Along Slow-Spreading Mid-Ocean Ridges [PDF]
Oceanography, 2012 In the classic mid-ocean ridge model, new seafloor is generated through a combination of magmatic diking feeding lava flows at the spreading axis, and the formation of short-offset, high-angle normal faults that dip toward the axis.
Deborah K. Smith +3 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Bringing Mid-Ocean Ridge Discoveries to Audiences Far and Wide: Emerging Trends for the Next Generation [PDF]
Oceanography, 2012 The "Ridge" community has pioneered not only scientific exploration of and research on the global mid-ocean ridge system but also innovative and attractive ways of reaching out to the public with fascinating stories of scientific discovery and cutting ...
Liz Goehring +2 more
doaj
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
A Vent-Field-Scale Model of the East Pacific Rise 9°50'N Magma-Hydrothermal System [PDF]
Oceanography, 2012 This paper describes a two-limb single-pass modeling approach constrained by vent temperature, heat flow, vent geochemistry, active-source seismology, and seismically inferred circulation geometry to provide first-order constraints on crustal ...
Robert P. Lowell +4 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Energy Transfer Through Food Webs at Hydrothermal Vents: Linking the Lithosphere to the Biosphere [PDF]
Oceanography, 2012 Tectonic and volcanic processes that drive hydrothermal fluid flow and influence its chemistry also regulate the transfer of energy to hydrothermal vent ecosystems.
Breea Govenar
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source