Results 81 to 90 of about 271,794 (297)

Hydrothermal Discharge During Submarine Eruptions: The Importance of Detection, Response, and New Technology [PDF]

open access: yesOceanography, 2012
Submarine volcanic eruptions and intrusions construct new oceanic crust and build long chains of volcanic islands and vast submarine plateaus. Magmatic events are a primary agent for the transfer of heat, chemicals, and even microbes from the crust to ...
Edward T. Baker   +5 more
doaj  

Geodetic measurements at sea floor spreading centers [PDF]

open access: yes
A network of 8 or more precision transponder units mounted on the sea floor and interrogated periodically from an instrument package towed near bottom through the area to provide the necessary spatial averaging could provide a practical system for ...
Spiess, F. N.
core   +1 more source

Neotectonics of the Sumatran fault, Indonesia [PDF]

open access: yes, 2000
The 1900-km-long, trench-parallel Sumatran fault accommodates a significant amount of the right-lateral component of oblique convergence between the Eurasian and Indian/Australian plates from 10°N to 7°S.
Natawidjaja, Danny, Sieh, Kerry
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

On the Potential for Bioenergy and Biofuels from Hydrothermal Vent Microbes [PDF]

open access: yesOceanography, 2012
The discovery of deep-sea hydrothermal vents caused scientists to reconsider their notions about life in the deep sea. In these seemingly inhospitable environments, free-living microbes, as well as microbial-animal symbioses, thrive in the warm waters ...
Peter R. Girguis, James F. Holden
doaj  

The Biggest Plates on Earth: Plate Tectonics [PDF]

open access: yes
In this lesson, students investigate the movement of Earth's tectonic plates, the results of these movements, and how magnetic anomalies present at spreading centers document the motion of the crust. As a result of this activity, students will be able to

core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Endeavour Segment of the Juan de Fuca Ridge: One of the Most Remarkable Places on Earth [PDF]

open access: yesOceanography, 2012
Endeavour Segment of the Juan de Fuca Ridge is one of three Integrated Study Sites for the Ridge 2000 Program. It is a remarkable, dynamic environment hosting five major hydrothermal fields, numerous smaller fields, and myriad diffuse-flow sites; magma ...
Deborah S. Kelley   +14 more
doaj  

Cerro prieto and its relation to the gulf of California spreading centers

open access: yesCiencias Marinas, 1996
The Cerro Prieto geothermal field is located in the Mexicali Valley, Baja California. Tectonically, this northern part of the Gulf of California has been classified as a spreading center, within a transitional area of oceanic to continental conditions ...
AL Quintanilla-Montoya, F Suárez-Vidal
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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