Results 81 to 90 of about 1,108,477 (248)
Bringing Mid-Ocean Ridge Discoveries to Audiences Far and Wide: Emerging Trends for the Next Generation [PDF]
Oceanography, 2012 The "Ridge" community has pioneered not only scientific exploration of and research on the global mid-ocean ridge system but also innovative and attractive ways of reaching out to the public with fascinating stories of scientific discovery and cutting ...
Liz Goehring +2 more
doaj
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Information spreading and development of cultural centers
, 2012 The historical interplay between societies is governed by many factors, including in particular the spreading of languages, religion, and other symbolic traits.
Dybiec, Bartłomiej +3 more
core +1 more source
A Vent-Field-Scale Model of the East Pacific Rise 9°50'N Magma-Hydrothermal System [PDF]
Oceanography, 2012 This paper describes a two-limb single-pass modeling approach constrained by vent temperature, heat flow, vent geochemistry, active-source seismology, and seismically inferred circulation geometry to provide first-order constraints on crustal ...
Robert P. Lowell +4 more
doaj
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Energy Transfer Through Food Webs at Hydrothermal Vents: Linking the Lithosphere to the Biosphere [PDF]
Oceanography, 2012 Tectonic and volcanic processes that drive hydrothermal fluid flow and influence its chemistry also regulate the transfer of energy to hydrothermal vent ecosystems.
Breea Govenar
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The role of libraries and information centers in building up information societies
Cybrarians Journal, 2007 This study aims at showing and reforming the role of libraries and information centers in men rooting and spreading out the religious and political doctrines as customs the tradition in side communities , and its role in facilitating dealing with recent ...
Ibrahim Nazmi, Raid Soliman
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source