Results 81 to 90 of about 270,633 (303)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

On the Potential for Bioenergy and Biofuels from Hydrothermal Vent Microbes [PDF]

open access: yesOceanography, 2012
The discovery of deep-sea hydrothermal vents caused scientists to reconsider their notions about life in the deep sea. In these seemingly inhospitable environments, free-living microbes, as well as microbial-animal symbioses, thrive in the warm waters ...
Peter R. Girguis, James F. Holden
doaj  

The Biggest Plates on Earth: Plate Tectonics [PDF]

open access: yes
In this lesson, students investigate the movement of Earth's tectonic plates, the results of these movements, and how magnetic anomalies present at spreading centers document the motion of the crust. As a result of this activity, students will be able to

core  

Safety and efficacy of endoscopic submucosal dissection for rectal neoplasia: a multicenter North American experience. [PDF]

open access: yes, 2019
Background and aims  Rectal lesions traditionally represent the first lesions approached during endoscopic submucosal dissection (ESD) training in the West. We evaluated the safety and efficacy of rectal ESD in North America.
Aadam, Abdul Aziz   +31 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Endeavour Segment of the Juan de Fuca Ridge: One of the Most Remarkable Places on Earth [PDF]

open access: yesOceanography, 2012
Endeavour Segment of the Juan de Fuca Ridge is one of three Integrated Study Sites for the Ridge 2000 Program. It is a remarkable, dynamic environment hosting five major hydrothermal fields, numerous smaller fields, and myriad diffuse-flow sites; magma ...
Deborah S. Kelley   +14 more
doaj  

Cerro prieto and its relation to the gulf of California spreading centers

open access: yesCiencias Marinas, 1996
The Cerro Prieto geothermal field is located in the Mexicali Valley, Baja California. Tectonically, this northern part of the Gulf of California has been classified as a spreading center, within a transitional area of oceanic to continental conditions ...
AL Quintanilla-Montoya, F Suárez-Vidal
doaj   +1 more source

From Social Data Mining to Forecasting Socio-Economic Crisis

open access: yes, 2011
Socio-economic data mining has a great potential in terms of gaining a better understanding of problems that our economy and society are facing, such as financial instability, shortages of resources, or conflicts.
A. Barabasi   +52 more
core   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

open access: yes
Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari   +9 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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