Results 161 to 170 of about 1,049,838 (245)

Cortical spreading depression induces propagating activation of the thalamus ventral posteromedial nucleus in awake mice. [PDF]

J Headache Pain, 2022
Fu X, Chen M, Lu J, Li P.
europepmc   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Mechanisms underlying the increased susceptibility to initiation of cortical spreading depression in a genetic mouse model of migraine. [PDF]

J Headache Pain
Vitale M, Tottene A, Zadeh MZ, Pietrobon D.   +3 more
europepmc   +1 more source

KCl-induced repetitive cortical spreading depression inhibiting trigeminal neuronal firing is mediated by 5-HT_1B/1D and opioid receptors. [PDF]

Cephalalgia, 2022
Supronsinchai W, Hoffmann J, Akerman S, Goadsby PJ.   +3 more
europepmc   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Have You Tried Restarting It? Cortical Spreading Depression Shuts Down Seizures by Short-Circuiting Electrical Propagation. [PDF]

Epilepsy Curr, 2022
Shuman T.
europepmc   +1 more source

Is there a role of calcitonin gene-related peptide in cortical spreading depression mechanisms?- argument con. [PDF]

J Headache Pain
Melo-Carrillo A.
europepmc   +1 more source

Study on "Atypical" Migraine Auras in the Pediatric Age: The Role of Cortical Spreading Depression and the Physiopathogenetic Hypothesis Arising from Our Clinical Cases. [PDF]

Life (Basel), 2022
Raieli V, Capizzi M, Marino A, Di Nardo G, Raucci U, Parisi P.   +5 more
europepmc   +1 more source

Bridging Horizontal to Vertical Radiative Cooling

Advanced Science, EarlyView.
Radiative cooling materials are mature but only work facing the sky, confining them to rooftops. Instead of developing new ones, this system bridges existing horizontal coolers to vertical windows using blades outside the glass. On an occupied urban building, windows stay up to 1.4°C below air temperature while preserving daylight, outward views, and ...
Xiangyu Meng, Gan Huang
wiley   +1 more source