Results 111 to 120 of about 437,891 (285)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
Results in PhysicsThe enhanced spreading of a 2D drop on a stiff and free-standing elastic thin film theoretically investigated by Shanahan (Rev. Phys. Appl. 1988, 23, 1031–1037) has not been studied and verified experimentally. To shed a light on this interesting problem,
Yanbo Yao +3 more
doaj +1 more source
Behaviors of a micro oil droplet in an EHL contact
Friction, 2016 Oil–air lubrication supplies lubricants in the form of droplets to elastohydrodynamic lubrication (EHL) contacts, such as those in high-speed spindle bearings.
Xinming Li +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Spatial dynamics of a nonlocal dispersal vector disease model with spatio-temporal delay
Electronic Journal of Differential Equations, 2015 This article concerns the spatial dynamics of a nonlocal dispersal vector disease model with spatio-temporal delay. We establish the existence of spreading speeds and construct some new types of solutions which are different from the traveling wave ...
Jia-Bing Wang +2 more
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FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
Chemical Engineering TransactionsIn this study, the effects of spreading speed and bed temperature on powder spreading in the Laser-Beam Powder Bed Fusion (PBF-LB) process were investigated. A purposely developed image analysis method was used to evaluate powder spread quality.
Bruno Nicola Dose +4 more
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