Results 11 to 20 of about 353,966 (351)

Detection and Analysis of Microplastics in Human Sputum.

Environmental Science and Technology, 2022
Microplastic pollution is an emerging environmental problem, and little research has focused on its impact on the human body. Based on retrospective case series, the study required participants to fill out a questionnaire and provide sputum samples in ...
Shumin Huang, Xiaoxin Huang, Ran Bi, Qiuxia Guo, Xiaolin Yu, Qinghui Zeng, Ziyu Huang, Tianming Liu, Haisheng Wu, Yuliang Chen, Jialong Xu, Ying-E Wu, P. Guo   +12 more
semanticscholar   +1 more source

Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist

Journal of Clinical Investigation, 2023
Background Lung infections are among the most consequential manifestations of cystic fibrosis (CF) and are associated with reduced lung function and shortened survival.
D. Nichols, Sarah J. Morgan, M. Skalland, A. Vo, J. V. Van Dalfsen, Sachinkumar Singh, W. Ni, L. Hoffman, Kailee McGeer, S. Heltshe, J. Clancy, S. Rowe, Peter Jorth, Pradeep K. Singh   +13 more
semanticscholar   +1 more source

Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies.

Cell Reports, 2021
In cystic fibrosis (CF) airways, Pseudomonas aeruginosa forms cellular aggregates called biofilms that are thought to contribute to chronic infection. To form aggregates, P.
Laura K. Jennings, Julia E. Dreifus, Courtney Reichhardt, K. M. Storek, Patrick R. Secor, D. Wozniak, K. B. Hisert, M. Parsek   +7 more
semanticscholar   +1 more source

COVID-19–related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection of host cells.
M. Peters, S. Sajuthi, P. DeFord, S. Christenson, C. Rios, M. Montgomery, P. Woodruff, D. Mauger, S. Erzurum, M. Johansson, Loren C. Denlinger, N. Jarjour, M. Castro, A. Hastie, W. Moore, V. Ortega, E. Bleecker, S. Wenzel, E. Israel, B. Levy, M. Seibold, J. Fahy   +21 more
semanticscholar   +1 more source

SARS-CoV-2–Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19

Annals of Internal Medicine, 2020
SARS-CoV-2–Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19 Background: The outbreak of coronavirus disease 2019 (COVID-19) has become a global public health problem.
Chen Chen, Gui-ju Gao, Yanli Xu, L. Pu, Qi Wang, Liming Wang, Wenling Wang, Yangzi Song, Meiling Chen, Linghang Wang, Feng-ting Yu, Siyuan Yang, Yun-xia Tang, Li Zhao, Huijuan Wang, Yajie Wang, H. Zeng, Fujie Zhang   +17 more
semanticscholar   +1 more source

The Sputum Microbiome, Airway Inflammation and Mortality in Chronic Obstructive Pulmonary Disease.

Journal of Allergy and Clinical Immunology, 2020
BACKGROUND The sputum microbiome has a potential role in disease phenotyping and risk stratification in chronic obstructive pulmonary disease but few large longitudinal cohort studies exist.
A. Dicker, J. Huang, M. Lonergan, Holly R. Keir, Christopher J. Fong, Brandon Tan, A. Cassidy, S. Finch, H. Mullerova, B. Miller, R. Tal-Singer, J. Chalmers   +11 more
semanticscholar   +1 more source

Comparison of throat swabs and sputum specimens for viral nucleic acid detection in 52 cases of novel coronavirus (SARS-Cov-2)-infected pneumonia (COVID-19)

medRxiv, 2020
Objectives In December 2019, a novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, China. Laboratory-based diagnostic tests utilized real-time reverse transcriptase polymerase chain reaction (RT-PCR) on throat samples.
Chenyao Lin, J. Xiang, Mingzhe Yan, Hongze Li, Shuang Huang, Changxin Shen   +5 more
semanticscholar   +1 more source

Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma.

Journal of Allergy and Clinical Immunology, 2020
BACKGROUND Whether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is unknown.
J. Durack, Laura S. Christian, S. Nariya, Jeanmarie R. Gonzalez, N. Bhakta, K. M. Ansel, A. Beigelman, M. Castro, A. Dyer, E. Israel, M. Kraft, Richard J. Martin, David T. Mauger, Stephen P. Peters, Sharon R. Rosenberg, C. Sorkness, M. Wechsler, Sally E. Wenzel, Steven R. White, Susan V. Lynch, Homer A. Boushey, Yvonne J Huang   +21 more
semanticscholar   +1 more source

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Gibson, Anthony, Holz, Olaf, Janicki, Stanislawa, Jörres, Rudolf A., Kanniess, Frank, Magnussen, Helgo, Richter, Kai, Simpson, Kathy J., Tal-Singer, Ruth, Vessey, Rupert S. J.   +9 more
core   +1 more source

MISLEADING SPUTUM CARTONS [PDF]

Journal of Clinical Pathology, 1960
Waxed paper sputum cartons obtained from the manufacturers contained very few organisms. Similar cartons which had been stored in hospital wards were often contaminated with hospital dust. This contamination was sometimes sufficiently marked to be misleading. Coliform organisms are particularly liable to cause confusion.
C G, THOMAS, F J, GIBBS
openaire   +2 more sources