Results 11 to 20 of about 2,356 (123)
Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in
BMC Microbiology, 2008 Background All aerobically grown living cells are exposed to oxidative damage by reactive oxygen species (ROS). A major damage by ROS to proteins is caused by covalent modifications of methionine residues giving methionine sulfoxide (Met-SO).
Martin-Verstraete Isabelle +5 more
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Stabilization of Bacillus subtilis Spx under cell wall stress requires the anti-adaptor protein YirB. [PDF]
PLoS Genetics, 2018 Spx is a global transcriptional regulator present in low-GC Gram-positive bacteria, including the model bacterium Bacillus subtilis and various human pathogens. In B. subtilis, activation of Spx occurs in response to disulfide stress.
Daniel F Rojas-Tapias, John D Helmann
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Frontiers in Microbiology, 2020 Bacterial cells respond to environmental stresses by modulating their gene expression and adjusting their proteome. In Staphylococcus aureus, selective degradation by ClpP protease eliminates damaged proteins and regulates the abundance of functional ...
Olesya O. Panasenko +5 more
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BMC Plant BiologyBackground Proteins harboring the SPX domain are crucial for the regulation of phosphate (Pi) homeostasis in plants. This study aimed to identify and analyze the entire SPX gene family within the cucumber genome.
Jialin Li +7 more
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CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis
Hepatology, EarlyView., 2022 A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang +18 more
wiley +1 more source
Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior
Biomolecules, 2022 Spexin (SPX) is a recently identified neuropeptide that is believed to play an important role in the regulation of energy homeostasis. Here, we describe a mediating function of SPX in hypothalamic leptin action.
Bora Jeong +8 more
doaj +1 more source
Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis. [PDF]
PLoS ONE, 2011 Spx is a global regulator of genes that are induced by disulfide stress in Bacillus subtilis. The regulon that it governs is comprised of over 120 genes based on microarray analysis, although it is not known how many of these are under direct Spx control.
Peter Zuber +9 more
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Human Nutrition & Metabolism, 2022 Objectives: Spexin (SPX) is a novel peptide hormone that lowers blood glucose levels and is protective against hepatic steatosis in diet induced obese mouse models.
Eman Salah Albeltagy +1 more
doaj +1 more source
Mechanisms for Bile Acids CDCA- and DCA-Stimulated Hepatic Spexin Expression
Cells, 2022 Spexin (SPX) is a novel peptide involved in glucose and lipid metabolism and suppresses hepatic total bile acid levels by inhibiting hepatic cholesterol 7α-hydroxylase 1 expression.
Qi Lai +10 more
doaj +1 more source