Serum Spexin Level Is Negatively Associated With Peripheral Neuropathy and Sensory Pain in Type 2 Diabetes [PDF]
Journal of Diabetes ResearchConclusions: These results suggested that spexin might serve as a protective factor for diabetes against neuropathology and pain-related pathogenesis.
Jiarong Dai, Rui Liu, Quanya Sun
exaly +3 more sources
Serum spexin levels in women with diminished ovarian reserve: a prospective case–control study [PDF]
Frontiers in MedicineBackgroundSpexin is a recently identified neuropeptide that modulates the hypothalamic–pituitary–gonadal axis and has been shown to regulate granulosa cell function.
Rumeysa Nur Ozkan +2 more
doaj +2 more sources
Biochemical, Immunohistochemical and Behavioral Effects of Spexin in a Methimazole-Induced Hypothyroidism Rat Model [PDF]
BiologyHypothyroidism is associated with metabolic, neurobehavioral, and reproductive alterations that may involve neuroendocrine regulatory peptides. Spexin, a neuropeptide implicated in energy homeostasis, has recently attracted attention for its possible ...
Seda Koçak +4 more
doaj +2 more sources
Frontiers in Veterinary Science, 2022 Spexin (SPX, NPQ), a novel neuropeptide composed of 14 amino acid residues, is evolutionarily conserved among different species. Spexin has been suggested to have pleiotropic functions in mammals. However, reports on spexin in birds are limited.
Huanxi Zhu, Mingming Lei, Zichun Dai
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Association between spexin and type 2 diabetes mellitus: a systematic review and meta-analysis [PDF]
Frontiers in EndocrinologyBackgroundAccumulating evidence suggests that spexin is implicated in cellular energy balance, glucose and lipid metabolism, appetite suppression, and water-electrolyte regulation, and is closely associated with metabolic conditions including obesity ...
Xin Sun +3 more
doaj +2 more sources
Emerging Roles of NPQ/Spexin in Physiology and Pathology
Frontiers in Pharmacology, 2019 Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide. Spexin gene and protein are widely expressed in central nervous system and peripheral tissues in humans, rodents, goldfish, etc.
Shuang-Yu Lv +2 more
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Circulating spexin levels in women with PCOS (PMOS): relationships with phoenixin, BMI and perceived stress [PDF]
BMC Endocrine DisordersBackground Polycystic ovary syndrome (PCOS), for which the term polyendocrine metabolic ovarian syndrome (PMOS) has recently been proposed to better reflect its complex endocrine and metabolic nature, is a common endocrine disorder associated with ...
Ekaterina Babadzhanova +5 more
doaj +2 more sources
Neuropeptide Alterations in Type 2 Diabetes Mellitus: A Meta‐Analysis of Circulating Spexin and Galanin Levels [PDF]
Endocrinology, Diabetes & MetabolismBackground Spexin and galanin are neuropeptides involved in glucose homeostasis, insulin sensitivity, appetite, and energy metabolism. We conducted a systematic review and meta‐analysis to synthesise evidence on circulating spexin and galanin ...
Roshan Kumar Mahat +4 more
doaj +2 more sources
Spexin Acts as Novel Regulator for Bile Acid Synthesis
Frontiers in Physiology, 2018 Spexin is a novel hormone involved in obesity and diabetes while its biofunctional significance in lipid metabolism is still to be comprehended. Global metabolomic analysis in the present study revealed multiple metabolic pathways altered by spexin ...
Tao Huang +2 more
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Investigation of Spexin Effects on Insulin‐Dependent Pathway Genes in High‐Glucose‐Induced Insulin‐Resistant C2C12 Myotubes [PDF]
FASEB BioAdvancesDiabetes is a global health concern, with type 2 diabetes mellitus (T2DM) being the most common form. T2DM is characterized by insulin resistance and impaired glucose uptake in skeletal muscle.
Ann Sze Cheah +3 more
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