Results 11 to 20 of about 863 (166)

The Effect of Exercise on Spexin and Follistatin in Elderly Individuals [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background In adipose tissue–muscle crosstalk mechanisms, the interaction of adipokines and myokines is known to be critical for maintaining the body's metabolic balance in age‐related metabolic disorders.
Elif Yıldırım Ayaz, Berna Dincer, Gülser Cinbaz, Esra Karacan, Reyhan Kaygusuz Benli, Emel Mete, Hilal Bilgiç, Banu Mesci   +7 more
doaj   +6 more sources

Peripheral Spexin Inhibited Food Intake in Mice [PDF]

International Journal of Endocrinology, 2020
Spexin (SPX, NPQ), a novel endogenous neuropeptide, was firstly identified by bioinformatics. Spexin gene and protein widely distributed in the central nervous system and peripheral tissues, such as the hypothalamus and digestive tract.
Shuangyu Lv, Yuchen Zhou, Yu Feng, Xiaomei Zhang, Xinyue Wang, Yanjie Yang, Xinchun Wang   +6 more
doaj   +4 more sources

Involvement of central opioid and melanocortin receptors in spexin-induced hypophagia following intracerebroventricular injection in neonatal broiler chicks [PDF]

BMC Veterinary Research
Background Numerous physiological properties have been documented in the literature pertaining to spexin, such as its role in appetite regulation. Therefore, the present research aimed to assess the impacts of centrally administering spexin and its ...
Mohanna Badri, Samad Alimohammadi, Morteza Zendehdel, Shahin Hassanpour   +3 more
doaj   +3 more sources

Advances in research on spexin-mediated regulation of reproductive function in vertebrates [PDF]

Frontiers in Endocrinology
Spexin (SPX, NPQ) is a 14-amino acid neuroactive peptide identified using bioinformatics. This amino acid sequence of the mature spexin peptide has been highly conserved during species evolution and is widely distributed in the central nervous system and
Xiaojing Chen, Yuyan Feng, Shudi Dai, Binbin Guo, Leyan Yan, Jie Liu, Huanxi Zhu   +6 more
doaj   +4 more sources

The role of Spexin and Phoenixin-20 in girls during puberty [PDF]

BMC Endocrine Disorders
Background Spexin has an inhibitory effect on the hypothalamus (GnRH expression), pituitary (LH and FSH expression) and ovary (estradiol expression). However, Phoenixin potentiate GnRH-stimulated GnRH receptor expression. Our aim is to assess the role of
Serkan Bilge Koca, Tarık Kırkgöz, Leyla Kara, Ebru Gök, Derya Koçer, Hüseyin Demirbilek   +5 more
doaj   +6 more sources

Spexin level in acute myocardial infarction in the emergency department [PDF]

Journal of Medical Biochemistry, 2023
Background: We aimed to determine the serum spexin level in patients with acute myocardial infarction (AMI) admitted to the emergency department. Methods: A total of 100 patients with AMI (50 with ST-segment elevation myocardial infarction (STEMI) and 50
Çiftçi Yahya, Gurger Mehtap, Gul Evrim, Yilmaz Mustafa, Telo Selda, Atescelik Metin, Cagri Goktekin Mehmet, Ali Kobat Mehmet   +7 more
doaj   +3 more sources

Associations Between Circulating Spexin, Obesity, and Insulin Resistance in Korean Children and Adolescents [PDF]

Nutrients
Background: Spexin is a neuropeptide involved in various physiological functions, including energy metabolism, appetite regulation, and weight loss.
Shin Hee Kim, Yoon Hong Chun
exaly   +3 more sources

Emerging roles of spexin in cardiovascular homeostasis. [PDF]

Front Cardiovasc Med
Spexin (SPX) is a highly conserved, proteolytically processed 14-amino acid peptide hormone derived from spexin precursor, originally identified through a bioinformatics-based prediction algorithm. SPX possesses pleiotropic effects across multiple organ system and has been implicated in the regulation of appetite, lipid and glucose metabolism ...
Wang S, Xie J, Li Z, Mao L, Dang X.
europepmc   +5 more sources

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents [PDF]

Journal of Clinical Medicine, 2019
The Spexin gene is considered the most dysregulated in obese human fat. Limited data suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity. The aim of this case-control study was to compare fasting serum spexin concentrations between normal weight (NW) and overweight/obese (OB/OW) adolescent ...
Flora Bacopoulou, Despoina Apostolaki, Aimilia Mantzou, Artemis Doulgeraki, Artur Pałasz, Pantelis Tsimaris, Eleni Koniari, Vasiliki Efthymiou   +7 more
core   +7 more sources

Anti-Inflammatory Effects of Spexin on Acetic Acid‑Induced Colitis in Rats via Modulating the NF-κB/NLRP3 Inflammasome Pathway. [PDF]

J Biochem Mol Toxicol
Spexin exhibits a therapeutic effect in ulcerative colitis. Spexin suppresses oxidative damage and neutrophil infiltration in the acetic acid induced ulcerative colitis rat model. Spexin reduces inflammation in ulcerative colitis by inhibiting the NLRP3 inflammasome pathway. Spexin suppresses the NF‐κB‐mediated increase in pro‐inflammatory cytokines in
Tamer SA, Köse F, Yanar S, Budak Ö, Bağcı C.   +4 more
europepmc   +3 more sources