Results 41 to 50 of about 863 (166)

Role of Spexin and Leptin in Obesity Among Male Pakistani Population [PDF]

Liaquat National Journal of Primary Care, 2020
Respected Editor, There is an increased prevalence of obesity with an off shoot of metabolic disorders in our part of the world. Obesity is considered as a leading complex disorder that has increased worldwide at shocking speed affecting mankind ...
Rabiya Ali, Mussarat Ashraf, Sher Khan
doaj   +1 more source

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III [PDF]

Endocrinology, 2014
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of this peptide is currently under investigation. Here, we identified SPX along with a second SPX gene (SPX2) in vertebrate genomes. Syntenic analysis and relocating SPXs and their neighbor genes on reconstructed vertebrate ancestral chromosomes revealed that SPXs ...
Dong-Kyu, Kim, Seongsik, Yun, Gi Hoon, Son, Jong-Ik, Hwang, Cho Rong, Park, Jae Il, Kim, Kyungjin, Kim, Hubert, Vaudry, Jae Young, Seong   +8 more
openaire   +2 more sources

Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model [PDF]

EndocrinologyJN, 2017
Spexin (SPX), a neuropeptide discovered by the bioinformatics approach, has been recently identified as a satiety factor in a fish model. However, the functional link between feeding and SPX expression as well as the signal transduction for SPX regulation are totally unknown.
Wong, AOL, Ma, A, Ko, WKW, Wong, MKH, He, M, Bai, J   +5 more
openaire   +4 more sources

The effect of eight weeks of 30-20-10 interval training on serum spexin levels and lipid profile in obese middle-aged men [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2023
Background and Purpose: The purpose of this study was to investigate the effect of 30-20-10 interval training on the serum spexin level and lipid profile of obese men in order to measure the effect of physical activity on increasing spexin and improving ...
Hamid Yazdanshenas, Roghayeh Fakhrpour, Bahloul Ghorbanian   +2 more
doaj   +1 more source

Changes in metabolic and hormonal profiles during transition period in dairy cattle – the role of spexin

BMC Veterinary Research, 2021
Background This study aimed to evaluate spexin as a novel blood marker and to describe the relationship of this peptide with selected biochemical metabolites measured during the transition period in dairy cows. Additionally, mRNA expression of the spexin
Robert Mikuła, Ewa Pruszyńska-Oszmałek, Marcin Pszczola, Justyna Rząsińska, Maciej Sassek, Krzysztof W. Nowak, Leszek Nogowski, Paweł A. Kołodziejski   +7 more
doaj   +1 more source

Serum spexin differed in newly diagnosed type 2 diabetes patients according to body mass index and increased with the improvement of metabolic status

Frontiers in Endocrinology, 2022
ObjectiveThe aim of this study was to explore serum spexin levels in newly diagnosed type 2 diabetes mellitus (T2DM) patients with different body mass indexes (BMIs) and to investigate the changes of spexin after improvement of metabolic indicators ...
Liping Gu, Shuai Yan, Yunhong Huang, Jiaying Yang, Yongde Peng, Yufan Wang   +5 more
doaj   +1 more source

Kisspeptin and Spexin: lipid profile and sperm parameters in infertile and fertile male subjects

Journal of University Medical & Dental College, 2021
BACKGROUND & OBJECTIVE: Kisspeptin (KP) and spexin (SPX) are neuropeptides that play a substantial role in metabolism and sexual function. Our objective is to explore the association of spexin and kisspeptin with sperm parameters and lipid profile in the
Muhammad Hasan Raza Raja , Mussarat Ashraf , Sher Khan , Nida Farooqui, Arfa Azhar, Rehana Rehman   +5 more
doaj   +1 more source

Decreased levels of spexin are associated with hormonal and metabolic disturbance in subjects with polycystic ovary syndrome

, 2021
Spexin, a newly identified peptide hormone, is involved in energy metabolism and the hypothalamic gonadal axis. We aimed to compare the altered levels of spexin in women with and without polycystic ovary syndrome (PCOS) and to find out if there was any ...
İsmail Demir, Aslı Guler
core   +1 more source

Low levels of spexin and adiponectin may predict insulin resistance in patients with non-alcoholic fatty liver

Practical Laboratory Medicine, 2021
Adipose tissue is endocrine organ that responds by secreting numerous hormones that regulate metabolism in skeletal muscle and the liver. The aim of this study was to compare the levels of spexin and adiponectin in patients with non-alcoholic fatty liver
Linxiang Zhang, Guangzhi Li, Yuqing She, Zhenwen Zhang   +3 more
doaj   +1 more source

Is Insulin Resistance the Driver or the Outcome of Diabetes Mellitus? A Critical Review. [PDF]

J Nutr Metab
Insulin resistance (IR) and Type 2 diabetes mellitus (DM) are intricately related metabolic conditions that significantly contribute to the global health burden. IR is characterized by chronic hyperglycemia that triggers a cascade of metabolic dysfunctions, including alterations in insulin signaling and the promotion of IR via inflammatory pathways ...
Shahid S, Qamar S, Qamar F, Fatima A, Máthé E, Khaliq M.   +5 more
europepmc   +2 more sources