Results 31 to 40 of about 863 (166)

Spexin is a biomarker of the process that regulates leptin sensitivity

Peptides
The rising prevalence of obesity poses a critical threat to global health, prompting an urgent need for a comprehensive understanding of its underlying mechanisms. This study aimed to delve into the relationship between obesity, leptin sensitivity, and gut hormones, focusing on spexin, glucagon-like peptide-1 (GLP-1), and gastric inhibitory polypeptide
Mohamed Badie Ahmed, Abdella M. Habib, Saif Badran, Abeer Alsherawi, Asma Syed, Hoda Khoogaly, Atalla Hammouda, Abdul-Badi Abou-Samra, Suhail A. Doi   +8 more
openaire   +4 more sources

Effect of spexin neuropeptide on the function of the pituitary-gonadal axis and ovarian follicles in mature female rats [PDF]

Journal of Advanced Biomedical Sciences, 2017
Background & Objectives: Neuropeptides are involved in various functions such as regulation of reproductive system function. With regards to the prevalence of reproductive disorders all over the world, this study is aimed at determining the effect of ...
Azam Saharagard, Seyyed Ebrahim Hosseini
doaj   +1 more source

Tissue-Specific Modulation of Spexin Expression in Diet-Induced Obese Male Rats: Comparative Effects of Aerobic Exercise and Metformin

Applied Sciences
Obesity, a major global health concern, is associated with systemic metabolic dysregulation. Spexin, a peptide implicated in appetite control and energy balance, may represent a biomarker and therapeutic target in obesity management.
İsa Aydemir, Vedat Çınar, Taner Akbulut, Mehmet Hanifi Yalçın, Yavuz Yasul, Berrin Tarakçi Gençer, Süleyman Aydın, Halil İbrahim Ceylan, Nicola Luigi Bragazzi   +8 more
doaj   +2 more sources

Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway

Nutrition & Metabolism
Background Spexin, a 14 amino acid peptide, has been reported to regulate obesity and its associated complications. However, little is known about the underlying molecular mechanism.
Bihe Zeng, Qin Shen, Bo Wang, Xuan Tang, Jiaqi Jiang, Yiming Zheng, Hongbiao Huang, Wenyu Zhuo, Wang Wang, Yang Gao, Xuan Li, Shuhui Wang, Wenjie Li, Guanghui Qian, Jie Qin, Miao Hou, Haitao Lv   +16 more
doaj   +2 more sources

Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models. [PDF]

Exp Physiol
Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Bahar MR, Orhan SU, Tekin C, Taslidere A, Ozcan M, Tekin S.   +5 more
europepmc   +2 more sources

Spexin Friend or Foe? Novel Role of Spexin During Thermogenesis of White Adipose Tissue [PDF]

Journal of the Endocrine Society, 2021
Abstract Spexin (SPX) is a novel adipokine playing an emerging role in metabolic diseases due to its involvement in carbohydrate homeostasis, weight loss, appetite control, gastrointestinal movement, among others. Moreover, plasma levels are reduced in obese and type II diabetic patients.
Gambaro, Sabrina E, Zubiria, Guillermina Maria, Giordano, Alejandra P, Harnichar, Ezequiel A, Portales, Andrea E, Giovambattista, Andrés   +5 more
openaire   +1 more source

Nephroprotective effect of spexin in dogs and cats. [PDF]

BMC Vet Res
Abstract Background Kidney disease is a common and clinically significant problem in dogs and cats, yet the underlying pathophysiological mechanisms remain incompletely understood. A large part of the research concerns the role of newly described peptides/proteins that may potentially be ...
Gogulski M, Pruszyńska-Oszmałek E, Leciejewska N, Szczepankiewicz D, Nowak M, Juzwik P, Sassek M, Włodarek J, Kołodziejski PA.   +8 more
europepmc   +3 more sources

Biochemical and Physiological Effects of Galanin in Health and Disease. [PDF]

FASEB J
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Mireles P, Wang Y, Rhodes K, DeMorrow S.
europepmc   +2 more sources

Effect of Fasting on the Spexin System in Broiler Chickens [PDF]

Animals, 2021
Spexin (SPX) is a highly conservative peptide hormone containing 14 amino acids and was discovered in 2007 by bioinformatics methods. However, nothing is yet known about its role in the metabolism of birds, including broilers. The aim of this study was to investigate the effect of short-term fasting (2, 4, and 8 h) on the concentration of SPX in blood ...
Paweł A. Kołodziejski, Ewa Pruszyńska-Oszmałek, Marcin Hejdysz, Maciej Sassek, Natalia Leciejewska, Kamil Ziarniak, Jakub Bień, Piotr Ślósarz, Marta Kubiś, Sebastian Kaczmarek   +9 more
openaire   +3 more sources

Spexin and Metformin Comparative Ameliorated Ovarian and Liver Function Changes in Letrozole-Induced Polycystic Ovary Syndrome in Rats (Histological, Biochemical, Immunohistochemical and Morphometric Study) [PDF]

The Egyptian Journal of Histology, 2022
Introduction: Polycystic ovary syndrome (PCOS) is characterized by polycystic ovarian follicle morphology, ovulatory dysfunction, hyperandrogenism and insulin resistance. Spexin has a role in satiety control, lipid and glucose metabolism. Metformin is an
Khaled Abulfadle, Husam Edrees, Nancy Hassan, Heba Mohammed   +3 more
doaj   +1 more source