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Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2023 Objective: To evaluate and compare theserum Spexin levels in women with and without polycystic ovary syndrome (PCOS) and to find if there is any association of Spexin levels with metabolic and hormonal parameters among PCOS women.
Maliha Shameem +4 more
doaj +3 more sources
Biomedicines, 2023 There are some initial suggestions in the literature that phoenixin, spexin, nesfatin-1 and kisspeptin may play a role in the pathogenesis of affective disorders.
Lena Cichoń +6 more
doaj +2 more sources
Association of Spexin Hormone Levels with Metabolic Disturbance in Women with Polycystic Ovarian Syndrome [PDF]
Diyala Journal of MedicineBackground: Polycystic ovarian syndrome is affecting around 5–15% of females. Spexin hormone, identified as neuropeptide Q, has been newly recognized by bioinformatics methods. Objective: To evaluate the relationship concerning levels of spexin hormone
Ruaa F. salih +4 more
doaj +2 more sources
The effect of spexin injection and its interaction with nitric oxide, serotonin, and corticotropin receptors on the central regulation of food intake in broilers [PDF]
IBRO Neuroscience ReportsComplex homeostatic control mechanisms are tools to adjust the food birds eat and their appetite. Birds and mammals differ in several ways considering food intake regulation.
Mohaya Farzin +4 more
doaj +2 more sources
Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour [PDF]
Nature Reviews Endocrinology, 2020 The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and their pathophysiological roles are increasingly the subject of investigation. Evidence suggests that these bioactive peptides play a role in the regulation of metabolism, pancreatic β-cell function, energy homeostasis, mood and behaviour in several species ...
Edouard G. Mills +4 more
openaire +4 more sources
Spexin Is Expressed in the Carotid Body and Is Upregulated by Postnatal Hyperoxia Exposure
, 2012 Spexin is a recently identified peptide which is expressed in many different endocrine and nervous tissues. Due to the absence of data regarding spexin expression in the carotid body, the first aim of the present study was to investigate, through immunohistochemistry and Real-Time PCR, the expression and distribution of spexin in the rat and human ...
PORZIONATO, ANDREA +8 more
core +6 more sources
Normalization of Spexin Levels in Patients with Obesity Submitted to Bariatric Surgery
Obesity Surgery, 2023 Spexin is expressed by white fat tissue and other endocrine organs. A negative correlation between spexin and gluco-lipidic metabolism, energy homeostasis, and food intake has been reported. The objectives of this study are (1) to compare spexin levels between patients with obesity (study group) and normal-weight subjects (control group); (2) to ...
Bufano, Annalisa +14 more
openaire +5 more sources
Novel hypothalamic pathways for metabolic effects of spexin
Pharmacological ResearchOne of the main underlying etiologies of type 2 diabetes (T2DM) is insulin resistance, which is most frequently caused by obesity. Notably, the deregulation of adipokine secretion from visceral adiposity has been identified as a crucial characteristic of
Penghua Fang +9 more
doaj +3 more sources
Spexin-based galanin receptor 2 agonist improves renal injury in mice with type 2 diabetes
Animal Cells and Systems, 2023 The spexin-based GALR2 agonist (NS200) is a novel drug, which has shown antidepressant and anxiolytic action in a recent experimental study. In this study, we investigated the effects of NS200 on renal injury in an animal model of type 2 diabetes.
Jin Joo Cha +8 more
doaj +2 more sources
Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior [PDF]
Biomolecules, 2022 Spexin (SPX) is a recently identified neuropeptide that is believed to play an important role in the regulation of energy homeostasis. Here, we describe a mediating function of SPX in hypothalamic leptin action.
Bora Jeong +8 more
doaj +3 more sources