Results 61 to 70 of about 863 (166)
Animals, 2023 In the expansive domain of neuropeptide investigation, spexin (SPX) has emerged as a captivating subject, exerting a significant impact on diverse physiological processes.
Aleksandra Dajnowska +7 more
doaj +1 more source
Spexin is associated with Painful Diabetic Peripheral Neuropathy [PDF]
, 2021 Abstract Background: Spexin exerts multiple functions in the regulation of energy metabolism and glucose homeostasis. Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and almost one-third of patients with DPN suffer from neuropathic pain. Recent studies have shown that Spexin has antinociceptive effect.
Lu Zhu +6 more
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Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li +11 more
wiley +1 more source
Impact of spexin on metabolic diseases and inflammation: An updated minireview
Experimental Biology and Medicine, 2022 Spexin (SPX) is a 14 amino acid length peptide hormone which was discovered using bioinformatic tools. It is extensively expressed in central and peripheral tissues and secreted into circulation in response to metabolic stress. Recent studies revealed that SPX acts as a multifunctional peptide in various metabolic processes such as body weight, food ...
İbrahim Türkel +2 more
openaire +3 more sources
, 2021 Chronic kidney disease is a major global public health problem. The peptide hormones adropin and spexin modulate many physiological functions such as energy balance and glucose, lipid and protein metabolism.
Avcı, Filiz +8 more
core +1 more source
Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.ABSTRACT Preeclampsia (PE) is a major cause of maternal and fetal morbidity and mortality during pregnancy. PE is characterized by widespread endothelial dysfunction in mothers and fetuses. The etiology of PE remains elusive, but the dysregulation of microRNAs (miRNAs) in endothelial cells may contribute to the pathogenesis of PE. We have reported that
Si‐yan Zhang +3 more
wiley +1 more source
Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes [PDF]
Scientific Reports, 2020 Abstract Spexin is a novel neuropeptide playing an emerging role in metabolic diseases such as obesity and diabetes via involvement in energy homeostasis and food intake. The present study investigated the effects of obesity and type 2 diabetes (T2D) on circulating levels of spexin and its modulation by physical ...
Abdelkrim Khadir +6 more
openaire +2 more sources
Spexin Hormone Signaling and Atrial Fibrillation: The Knowns and Unknowns. [PDF]
CirculationHeijman J, Dobrev D.
europepmc +4 more sources
Frontiers in Endocrinology, 2021 Spexin (SPX), a highly conserved neuropeptide, is known to have diverse functions and has been implicated/associated with pathological conditions, including obesity, diabetes, anorexia nervosa, and anxiety/mood disorders.
Matthew K. H. Wong +6 more
doaj +1 more source
Topical Imiquimod in Mycosis Fungoides: A Systematic Review of Published Clinical Evidence
Dermatologic Therapy, Volume 2026, Issue 1, 2026.Background Topical imiquimod has been used as a skin‐directed treatment in selected patients with mycosis fungoides, but the available evidence remains limited and scattered across case reports, case series, pilot studies, retrospective cohorts, and preliminary conference data.
Kerem Balan +2 more
wiley +1 more source