Results 81 to 90 of about 863 (166)

Primary cilia, A‐kinase anchoring proteins and constitutive activity at the orphan G protein‐coupled receptor GPR161: A tale about a tail

British Journal of Pharmacology, Volume 181, Issue 14, Page 2182-2196, July 2024.
Primary cilia are non‐motile antennae‐like structures responsible for sensing environmental changes in most mammalian cells. Ciliary signalling is largely mediated by the Sonic Hedgehog (Shh) pathway, which acts as a master regulator of ciliary protein transit and is essential for normal embryonic development.
Kinjal Patel, Nicola J. Smith
wiley   +1 more source

Pharmacological Characterisation of Spexin Peptides at GPR161 and GAL2 Receptors

As of 2025, GPCRs comprise 36% of all approved drugs on the global market, acting on more than 120 GPCRs, out of the ~800 GPCRs encoded for by the human genome.
Patel, Kinjal
core   +1 more source

Impact of novel amino acid substituted and acylated spexin analogues on pancreatic beta-cell function, appetite and glucose homeostasis [PDF]

Objective: The neuropeptide spexin is recognised as a satiety-inducing hormone, but overall effects on metabolism are less characterised. Rapid enzymatic metabolism means elucidating biological effects of spexin is challenging, because the bioactive ...
Irwin, Nigel, O'Harte, Finbarr P M, Patterson, Steven; id_orcid, Gallagher, Daniel M., Khan, Md Zahidul Islam, Gallagher, Daniel M, Patterson, Steven, O'Harte, Finbarr P.M., Irwin, Nigel; id_orcid   +8 more
core   +1 more source

Long‐term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co‐administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus

The FASEB Journal, Volume 38, Issue 7, 15 April 2024.
Enhancing neurogenesis and antidepressant effects via intranasal GALR2 and Y1R agonists in the ventral hippocampus. This study illustrates the potentiation of neurogenesis and the antidepressant response following intranasal co‐administration of GALR2 and Y1R agonists.
Rasiel Beltran‐casanueva, Aracelis Hernández‐García, Pedro Jesús Serrano‐Castro, Jose Andrés Sánchez‐Pérez, Miguel Angel Barbancho‐Fernández, Natalia García‐Casares, Kjell Fuxe, Dasiel O. Borroto‐Escuela, Manuel Narváez   +8 more
wiley   +1 more source

Spexin in Metabolic Syndrome-An Overview

SAS Journal of Medicine, 2021
  Tejaswi Gowdu, Dayanand. CD
openaire   +1 more source

Serum levels of Neuropeptide Q, Orexin and Galanin in Hyperemesis Gravidarum [PDF]

International Journal of Medical Arts
Background: Hyperemesis gravidarum [HG] is a common pregnancy-associated condition with marked effects on quality of life and long-term adverse effects on the mother and her offspring.
Ismail A. Elhefnawy, Alaa Eldin Mahmoud Megahed   +1 more
doaj   +1 more source

The Evaluation of New Generation Inflammatory Markers in Children With Morbid Obesity and Metabolic Syndrome

Namık Kemal Tıp Dergisi, 2020
Aim: Technological advancements, unbalanced nutrition, sedentary life style, are important factors in obesity. Obesity-inflammation relationis beingexamined.
Mustafa Metin DONMA, Sevgi Dilan ERSELCAN, Ahsen YILMAZ, Savaş GUZEL, Orkide DONMA   +4 more
doaj   +1 more source

Evaluation of Serum Spexin Levels and their Correlation with Annexin A2 in Men with Rheumatoid Arthritis

Background: Rheumatoid Arthritis is a chronic joint synovial arthritic joint deterioration. The identification of novel biomarkers is crucial for improving diagnostic accuracy and understanding disease pathogenesis.
Shakir F. T. Alaaraji, Maryam M. F. Almuhammdi, Nibras Basim Mohammed   +2 more
core   +1 more source

Levels of a novel metabolic marker, spexin in patients with hirsutism: metabolic syndrome risk in idiopathic and polycystic ovarian syndrome (PCOS) hirsutism [PDF]

Objectives: Polycystic ovarian syndrome (PCOS) disease the most common endocrinopathy among reproductive age women, and its association with metabolic syndrome is investigated in many reports. The most common cause of hirsutism worldwide is considered to
Kilic, Berna Sermin, Selek, Sahabettin, Atakul, Nil, Atamer, Yildiz   +3 more
core   +3 more sources

Evaluation of Nesfatin–1 levels in ewes with pregnancy toxemia

Revista Científica
The goal of the present research was to investigate the effects of pregnancy toxemia (PT) on nesfatin–1 levels in ewes and to examine its relationship with spexin, another biomarker involved in energy metabolism.
Ömer Yaprakci, Tuğra Akkuş
doaj   +1 more source