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Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene [PDF]
Journal of Agricultural and Food Chemistry, 2020 Squalene has wide applications in the food and pharmaceutical industries. Engineering microbes to produce squalene is a promising alternative for traditional production approaches.
Bei Gao, Feng-Qing Wang, Yuhong Ren
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Vaccination, squalene and anti-squalene antibodies: Facts or fiction?
European Journal of Internal Medicine, 2010Squalene, a hydrocarbon obtained for commercial purposes primarily from shark liver oil and other botanic sources, is increasingly used as an immunologic adjuvant in several vaccines, including seasonal and the novel influenza A (H1N1) 2009 pandemic flu vaccines.
Giuseppe, Lippi +2 more
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Squalene in Petroleum Asphaltenes
Science, 1981Squalene, 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene, a new biological marker, has been detected in various petroleum asphaltenes and their pyrolysis products. Since squalene is the most common triterpenoid in nature and the biological precursor of the important tetra- and pentacyclic triterpane markers, its detection in asphaltene ...
N, Samman +4 more
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Journal of the American Chemical Society, 2002
Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphosphate (PSPP) and the subsequent rearrangement and NADPH-dependent reduction of PSPP to squalene (SQ). These reactions are the first committed steps in cholesterol biosynthesis.
Brian S J, Blagg +3 more
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Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphosphate (PSPP) and the subsequent rearrangement and NADPH-dependent reduction of PSPP to squalene (SQ). These reactions are the first committed steps in cholesterol biosynthesis.
Brian S J, Blagg +3 more
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[9] Synthesis of labeled squalene and squalene 2,3-oxide
1969Publisher Summary Squalene 2,3-oxide is an intermediate in the enzymatic cyclization of squalene to lanosterol, and, in consequence, this aspect of steroid and terpenoid biogenesis has become the center of renewed interest. This chapter describes the improved methods for the chemical synthesis of labeled squalene and squalene 2,3-oxide.
R.G. Nadeau, R.P. Hanzlik
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Synthesis, 1970
Wittig reactions of the ylide (Ph3P+CH-)2CH2 (I) with aliphatic aldehydes and ketones are described. A soln. of I in THF prepd. from (Ph3P+CH2)2CH2.2Br- was treated with an equimolar amt. of geranylacetone to give a stereoisomeric mixt. of II (norsqualene), b0.001 172-4 Deg, in 25% yield. III, b1 114-17 Deg, was similarly prepd.
Schlosser, Manfred, Piskala, Alois
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Wittig reactions of the ylide (Ph3P+CH-)2CH2 (I) with aliphatic aldehydes and ketones are described. A soln. of I in THF prepd. from (Ph3P+CH2)2CH2.2Br- was treated with an equimolar amt. of geranylacetone to give a stereoisomeric mixt. of II (norsqualene), b0.001 172-4 Deg, in 25% yield. III, b1 114-17 Deg, was similarly prepd.
Schlosser, Manfred, Piskala, Alois
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Chemical & Engineering News Archive, 1997
Chemists at the University of Utah, Salt Lake City, have trapped a cationic intermediate in the biosynthesis of squalene, a key precursor of cholesterol. Their insights into the remarkable enzymatic reaction may offer important leads to the design of drugs that reduce cholesterol levels by blocking squalene biosynthesis.
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Chemists at the University of Utah, Salt Lake City, have trapped a cationic intermediate in the biosynthesis of squalene, a key precursor of cholesterol. Their insights into the remarkable enzymatic reaction may offer important leads to the design of drugs that reduce cholesterol levels by blocking squalene biosynthesis.
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Metabolic engineering of Yarrowia lipolytica for improving squalene production
Bioresource Technology, 2021Yun Tian, Hu-Hu Liu, Xiao-Jun Ji
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