Results 181 to 190 of about 201,440 (215)

Heterogeneity of Head and Neck Squamous Cell Carcinoma Stem Cells

2019
Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk ...
Qian, Xu, Nie, Xiaobo, Wollenberg, Barbara, Sudhoff, Holger, Kaufmann, Andreas M., Albers, Andreas E., Birbrair, Alexander   +6 more
openaire   +3 more sources

Cell Kinetics of Head and Neck Squamous Cell Carcinomas: Prognostic implications

Acta Oncologica, 1994
Forty-three squamous cell carcinomas of the head and neck region were in vivo labelled with the thymidine analogue iododeoxyuridine. Combined flow cytometric (FCM) and immunohistochemical (IHC) analysis was performed, and the following parameters calculated: labelling index (LI), S-phase time (TS) and potential tumor doubling time (Tpot).
K, Nylander, G, Anneroth, H, Gustafsson, G, Roos, R, Stenling, B, Zackrisson   +5 more
openaire   +2 more sources

Cetuximab In Squamous Cell Carcinoma of the Head and Neck

Future Oncology, 2006
Surgery and radiotherapy are the standard treatment options for patients with squamous cell carcinoma of the head and neck (SCCHN). Chemotherapy and chemoradiotherapy are new alternatives for locally advanced disease, particularly induction chemotherapy for patients with unresectable tumors.
Ricardo, Hitt, Patricia, Martín, Manuel, Hidalgo   +2 more
openaire   +2 more sources

Role of cytokines in head and neck squamous cell carcinoma

Expert Review of Anticancer Therapy, 2006
Head and neck squamous cell carcinoma is one of the most frequent cancers and standard treatment has only marginally improved the 5-year survival rate of patients with this disease in the last few decades. It is supposed that cytokine alterations in immune, inflammatory and angiogenetic regulatory routes within the head and neck squamous cell carcinoma
Ralph, Pries, Stefan, Nitsch, Barbara, Wollenberg   +2 more
openaire   +2 more sources

Spectral Karyotyping Analysis of Head and Neck Squamous Cell Carcinoma

The Laryngoscope, 2001
AbstractObjectives/Hypothesis The genetic content of head and neck squamous cell carcinomas is ill defined. Spectral karyotyping (SKY) is a new technique that allows the simultaneous detection of all chromosomal translocations by labeling each individual chromosome with different fluorescent agents.
B, Singh, S, Gogineni, A, Goberdhan, P, Sacks, A, Shaha, J, Shah, P, Rao   +6 more
openaire   +2 more sources

Retrospective DNA Analysis of Head and Neck Squamous Cell Carcinoma

Archives of Otolaryngology - Head and Neck Surgery, 1986
Abnormal cellular DNA content, a hallmark of malignancy, is known to occur in squamous cell carcinoma of the head and neck. The significance of this finding has yet to be elucidated. Paraffin-embedded blocks from 46 squamous cell carcinomas of the head and neck were sectioned, dewaxed, and made into a suspension of bare nuclei by mechanical mincing and
A S, Kaplan, D D, Caldarelli, M S, Chacho, D R, Bruce, J, Hutchinson, S, Conway, J S, Coon   +6 more
openaire   +2 more sources

Expression of galectins in head and neck squamous cell carcinoma

Head & Neck, 1996
Galectins are carbohydrate-binding proteins thought to be important for cell growth and differentiation, whose expression is altered in some tumors with aggressive phenotype. Our objective was to evaluate the expression of galectins in head and neck squamous cell carcinoma (HNSCC).Fourteen HNSCC cell lines and four primary tumor specimens were ...
A, Gillenwater, X C, Xu, A K, el-Naggar, G L, Clayman, R, Lotan   +4 more
openaire   +2 more sources

Squamous Cell Carcinoma of the Head and Neck

1995
A wide variety of tumor types arising from different tissues are included under the heading of “head and neck cancer.” This review is concerned with squamous cell carcinomas arising from the surface epithelium of the upper respiratory and alimentary tract, which includes the oral cavity, pharynx, larynx, and paranasal sinuses.
E. W. Strong, H. Kasdorf, J. M. Henk
openaire   +1 more source

Expression of cdk6 in head and neck squamous cell carcinoma

Clinical Oral Investigations, 2015
Cdk6 is a key regulator during the G1/S cell cycle transition. Aberrant expression of cdk6 protein has been observed in many cancer types. However, little is known about the expression of cdk6 in head and neck squamous cell carcinoma (HNSCC) and its clinical significance.
Sopee, Poomsawat, Sirima, Sanguansin, Jirapa, Punyasingh, Paisarn, Vejchapipat, Phaibul, Punyarit   +4 more
openaire   +2 more sources

Allelotype of head and neck squamous cell carcinoma.

Cancer research, 1994
To gain a better understanding of the molecular changes in head and neck squamous cell carcinoma, we tested every autosomal arm of 29 primary head and neck tumors for allelic loss. Fifty-eight microsatellite markers were used with at least two-thirds of patients informative for each chromosomal arm tested.
H, Nawroz, P, van der Riet, R H, Hruban, W, Koch, J M, Ruppert, D, Sidransky   +5 more
openaire   +1 more source