Results 171 to 180 of about 31,301 (241)

Clinical Applications of 3D Specimen Scanning and Margin Mapping in Musculoskeletal Oncology: A 36 Patient Case Series

open access: yesJournal of Surgical Oncology, EarlyView.
ABSTRACT Background Text‐based pathology reports inadequately communicate complex three‐dimensional (3D) relationships in musculoskeletal oncology, potentially contributing to errors in re‐resection and adjuvant treatment planning. While our prior 7‐case pilot study established technical feasibility, the scalability of this workflow and its utility as ...
Riley S. Gilbertson   +11 more
wiley   +1 more source

Beyond Skin and Eyes: The Medical and Social Burden of Oculocutaneous Albinism in Africa: A Narrative Review

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni   +3 more
wiley   +1 more source

Sun Protection Behaviours in Skin Cancer Survivors: A Systematic Review and Meta‐Analysis

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Skin cancer, including melanoma and non‐melanoma skin cancer (NMSC), is one of the most prevalent cancers worldwide. Although sun protection behaviors, such as sunscreen use, protective clothing, and shade‐seeking, are crucial in preventing skin cancer recurrence and secondary malignancies, adherence to these behaviors among ...
Shubham Kumar   +3 more
wiley   +1 more source

The Physician Global Assessment as a Proxy for Photoaging: Validation in an Observational Real‐World Cohort Using SCINEXA as the Reference Standard

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Photoaging is a chronic skin condition caused by cumulative ultraviolet exposure superimposed on intrinsic aging. Although the SCore of INtrinsic and EXtrinsic skin Aging (SCINEXA) is a validated multidimensional instrument for assessing photoaging, the Physician Global Assessment (PGA) is a simpler clinician‐reported measure whose ...
Ewout Baerveldt   +6 more
wiley   +1 more source

Rhaponticin Blocks Glycolysis‐Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF‐1α Activity Inhibition

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Yuan Wu   +7 more
wiley   +1 more source

Heterogeneity Analyzed by CT‐Based Habitat Analysis for Clinical Management of Cancers: A Narrative Review

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tumors are highly heterogeneous, and whole‐lesion radiomics analysis is a popular method for extracting texture features that reflect this heterogeneity, which can be used to build models for cancer diagnosis, staging, therapy response evaluation, and prognosis prediction.
Yang Zhang   +2 more
wiley   +1 more source

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang   +3 more
wiley   +1 more source

Effects of Ferrostatin‐1 on Vocal Folds in Aging Rats

open access: yesThe Laryngoscope, EarlyView.
Age‐related vocal fold degeneration is associated with oxidative stress, and ferroptosis may contribute to structural changes in aging vocal folds. In this aged rat model, intracordal injection of the antioxidant ferrostatin‐1 attenuated ferroptosis‐related changes and was associated with modulation of collagen accumulation, hyaluronic acid ...
Yong‐Il Cheon   +8 more
wiley   +1 more source

Effects of Intubation Duration on Trachea: A Histopathological Study

open access: yesThe Laryngoscope, EarlyView.
This study evaluated the histopathological effects of prolonged endotracheal intubation on the human trachea using biopsy specimens obtained during tracheotomy. Prolonged intubation was associated with progressive inflammatory and structural changes, with tracheal dilatation and perichondritis increasing significantly after 14 days.
Osman Kilic   +6 more
wiley   +1 more source

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