Results 151 to 160 of about 31,301 (241)

Neoadjuvant Cemiplimab for Resectable Locoregionally Advanced Cutaneous Squamous Cell Carcinoma: A Case Series

Head &Neck, EarlyView.
ABSTRACT Introduction A Phase II trial demonstrated that neoadjuvant cemiplimab was associated with pathologic complete response (pCR) in 51% of patients with locoregionally advanced cutaneous squamous cell carcinoma (cuSCC). We evaluated real‐world radiographic and pathologic responses to neoadjuvant cemiplimab and assessed radiologic–pathologic ...
Whitney Jin, Ryan K. Rigsby, Kim Ely, Austin Hoke, Robert Sinard, Kyle Mannion, Jill Gilbert, Lindsay Mundy, Alexander Langerman, Sarah Rohde, Barbara Murphy, Eben Rosenthal, Mitra Mehrad, Michael C. Topf, Jennifer H. Choe   +14 more
wiley   +1 more source

Aggressive Mandibular Squamous Cell Carcinoma Mimicking Periodontal Disease in a Non‐Transplanted Patient With Fanconi Anemia

Head &Neck, EarlyView.
ABSTRACT Background Fanconi anemia (FA) is associated with markedly increased risk for early‐onset oral squamous cell carcinoma (OSCC). Methods We report an aggressive mandibular squamous cell carcinoma in a 26‐year‐old non‐transplanted woman with FA initially interpreted as localized periodontal disease adjacent to a tongue leukoplakia.
Cassius Carvalho Torres‐Pereira, Laura Grein Cavalcanti, Marta Aparecida Alberton Nuernberg, Juliana Lucena Schussel, José Miguel Amenábar Céspedes   +4 more
wiley   +1 more source

Bone‐Anchored Implant Survival in Oncologic Facial Prosthetic Rehabilitation

Head &Neck, EarlyView.
ABSTRACT Background Published survival rates for bone‐anchored craniofacial implants exceed 85%, but derive largely from mixed populations. Whether these apply to head and neck oncologic surgery remains uncertain. Methods Retrospective survival analysis of implants placed for prosthetic rehabilitation following extirpative surgery at a UK center (2005 ...
Oliver Blanshard, Sarah Jones, Peter M. Clarke, Jonathan M. Bernstein   +3 more
wiley   +1 more source

The Silent Masquerade: Hypopharyngeal Squamous Cell Carcinoma Presenting as Recurrent Deep Neck Abscess in a Young Adult: A Case Report and Literature Review

International Journal of Medical Students
Background: Deep neck space infections are common otolaryngologic emergencies that usually have a bacterial origin. However, a rare subset of head and neck squamous cell carcinomas (HNSCC) can present as cystic, necrotic masses that clinically mimic ...
Muhammad Suliman Sajid, Sheeza Afzal, Shayan Asmat, Muhammad Haris, Ameena Nasir, Muhammad Amir Sohail, Muhammad Osama Afzal, Uzair Asad   +7 more
doaj  

Complete Pathologic Response to Neoadjuvant Pembrolizumab Captured on Intraoperative PET/CT: A Case Report and Exploratory Analysis

Head &Neck, EarlyView.
ABSTRACT Background Neoadjuvant immunotherapy is an emerging treatment for patients with head and neck cancer. Given the heterogeneity of response, novel methods of intraoperative tumor and margin assessment warrant investigation. Methods A 55‐year‐old male presented with a cT3N2c supraglottic squamous cell carcinoma with a combined positive score of 5.
Joaquin Austerlitz, Andreja Radevic, Ashtyn McAdoo, Kyrionna Golliday, Cassie Pan, Annie Moroco, Spencer Roark, Michael C. Topf   +7 more
wiley   +1 more source

Pattern of Failure in Nasopharyngeal Carcinoma After Radiotherapy in a Low‐Incidence Population: A DAHANCA Study

Head &Neck, EarlyView.
ABSTRACT Background Nasopharyngeal carcinoma (NPC) is uncommon in many populations. Most existing clinical evidence comes from endemic areas, where Epstein–Barr virus (EBV)‐associated subtypes predominate. We analyzed patterns of failure in a population‐based cohort from Denmark, a low‐incidence setting.
Anne Marie Lindegaard, Katrin Haakansson, Maria Andersen, Mogens Bernsdorf, Jesper G. Eriksen, Mohammad Farhadi, Lisa L. Hjalgrim, Kenneth Jensen, Giedrius Lelkaitis, Christian Maare, Jens Overgaard, Christina Caroline Plaschke, Erik Schiess, Ruta Zukuskaite, Jeppe Friborg   +14 more
wiley   +1 more source

Characterization of Perineural Invasion Parameters for Risk Stratification in Oral Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Perineural invasion (PNI) is an established adverse prognostic factor in oral squamous cell carcinoma (OSCC), but the implications of its extent as well as its relationship with surgical margin status and the extent of microscopic tumor spread remain unclear.
Michael A. Müller, Muriel D. Brada, Niels J. Rupp, Cosima E. Riemenschnitter, Simon Müller, Alexander M. Huber, Panagiotis Balermpas, Grégoire B. Morand   +7 more
wiley   +1 more source

Prognostic Impact of Lymphovascular Invasion on Distant Metastasis in HPV‐Negative Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Lymphovascular invasion (LVI) is a recognized poor prognostic factor in head and neck squamous cell carcinoma (HNSCC), particularly for regional recurrence and overall survival. However, its role in predicting distant metastasis, especially in HPV‐negative HNSCC, remains unclear. Objective To evaluate the association between LVI and
Mark Khoury, Alex Mlynarek, Keith Richardson, Nader Sadeghi, Michael Hier, Christina Tsien, George Shenouda, Khalil Sultanem, Nathaniel Bouganim, Khashayar Esfahani, Sabrina Wurzba, Marco Mascarella   +11 more
wiley   +1 more source

Predictors of Delayed and Omitted Postoperative Radiotherapy After Laryngectomy for pT4 Laryngeal Cancer

Head &Neck, EarlyView.
ABSTRACT Background Postoperative radiotherapy (PORT) improves locoregional control and survival in high‐risk head and neck cancer, and guidelines recommend initiation within 42 days of surgery. Timeliness after laryngectomy for pathologic T4 (pT4) laryngeal cancer is poorly characterized.
George Ashji, Arun Rajan, Elias Dahl, Sudarshan Ramanan, Nishant Chadha, Yingzhi Wu, Richard J. Wong, Marc A. Cohen, Edward Christopher Dee, Nancy Y. Lee   +9 more
wiley   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source