Results 71 to 80 of about 141,551 (313)

MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells [PDF]

, 2011
Background: Esophageal squamous cell carcinoma (ESCC) is often diagnosed at later stages until they are incurable. MicroRNA (miR) is a small, non-coding RNA that negatively regulates gene expression mainly via translational repression.
Yamashita, S., Nakayama Toshiyuki, Matsushima Kayoko, Nagayasu, T., Inoue, N., Hidaka, S., Ohtsuru Akira, Yibin Kang, Hayashi, T., Hajime Isomoto, Masaki Kunizaki, Shigeru Kohno, Mitsutake Norisato, Hidaka Shigekazu, Ohtsuru, A., Takeshi Nagayasu, Naoki Inoue, Nakao Kazuhiko, Mitsutake, N., Nakashima Masahiro, Yamaguchi Naoyuki, Gregory Philip A, Kang Yibin, Matsushima, K., Isomoto Hajime, Ujifuku Kenta, Goodall, G., Kenta Ujifuku, Machida Haruhisa, Nakayama, T., Yamaguchi, N., Korpal Manav, Tomayoshi Hayashi, Kang, Y., Norisato Mitsutake, Philip A Gregory, Naoyuki Yamaguchi, Yamashita Shunichi, Haruhisa Machida, et al., Nagayasu Takeshi, Kohno, S., Machida, H., Nakashima, M., Manav Korpal, Shigekazu Hidaka, Kunizaki, M., Inoue Naoki, Toshiyuki Nakayama, Shunichi Yamashita, Akira Ohtsuru, Goodall Gregory J, Gregory J Goodall, Korpal, M., Kazuhiko Nakao, Isomoto, H., Hayashi Tomayoshi, Gregory, P., Ujifuku, K., Kunizaki Masaki, Kayoko Matsushima, Masahiro Nakashima, Kohno Shigeru   +62 more
core   +2 more sources

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Molecular Characterization of ‘p53 Family Network’ in Human Head and Neck Cancer and Anti-EGFR Therapy [PDF]

, 2008
Understanding of p53 family protein (p53, p63 and p73) networks in head and neck squamous cell carcinoma (HNSCC), can positively influence in cancer screening, diagnosis, treatment and prevention.
Sebastian, Sinto
core  

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Easily detected signs of perineural tumour spread in head and neck cancer

Insights into Imaging, 2018
Perineural tumour spread (PNTS) in head and neck oncology is most often caused by squamous cell carcinoma. The most frequently affected nerves are the trigeminal and facial nerves. Up to 40% of patients with PNTS may be asymptomatic. Therefore, the index
Jan Willem Dankbaar, Frank A. Pameijer, Jeroen Hendrikse, Ilona M. Schmalfuss   +3 more
doaj   +1 more source

Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G(2) delay and mitotic defects [PDF]

, 2013
Work by JP is funded by a Royal Society University Research Fellowship award. Experiments carried out by MBP were supported by the Department of Pathology, Albert Einstein College of Medicine / Montefiore Medical Center.The development of clinically ...
Parish, Joanna, Kawachi, Nicole, Loudig, Olivier, Feeney, Katherine, Antkowiak, Maciej, Prystowsky, Michael, Wasson, Christopher, Parish, Joanna; id_orcid, Willmott, Michelle, Montagna, Cristina   +9 more
core   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

ASSESSMENT OF BLOOD SERUM PROTEOME IN PATIENTS WITH SQUAMOUS CELL HEAD AND NECK CARCINOMA

Сибирский онкологический журнал, 2016
We compared the serum proteome profiles of squamous cell head and neck carcinoma patients with metastases, without metastases and healthy volunteers using the combination of gradient gel-electrophoresis (1D-SDS PAGE) and mass-spectrometry.
G. V. Kakurina, I. V. Kondakova, E. L. Choinzonov, D. A. Shishkin, O. V. Cheremisina   +4 more
doaj  

CO2 lasers in the management of potentially malignant and malignant oral disorders [PDF]

, 2012
The CO2 laser was invented in 1963 by Kumar Patel. Since the early 1970s, CO2 laser has proved to be an effective method of treatment for patients with several types of oral lesions, including early squamous cell carcinoma.
Waseem Jerjes, Zaid Hamdoon, Colin Hopper, Hamdoon, Z, Hopper, C, Jerjes, W   +5 more
core   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source