Results 101 to 110 of about 2,257 (201)

Synthesis of Squaric Acid Monoamides as Building Blocks for Drug Discovery

SynOpen, 2023
Nathan Long, Adam Le Gresley, Arran Solomonsz, Antony Wozniak, Steve Brough, Stephen P. Wren   +5 more
doaj   +1 more source

Enantioselective aza-Henry reaction of t-Boc protected imines and nitroalkanes with bifunctional squaramide organocatalysts

, 2016
A quinine-derived sterically encumbered squaramide organocatalyst afforded high enantioselectivity and excellent conversion in an aza-Henry reaction performed with imines and nitroalkanes.
Cihangir Tanyeli, SUSAM, DİLŞAD, Tanyeli, Cihangir, Susam, Zeynep Dilşad, Dilşad Susam   +4 more
core   +1 more source

Preclinical evaluation and automated synthesis of [89Zr]ZrDFOSquaramide-girentuximab for diagnostic imaging of carbonic anhydrase IX positive tumours

EJNMMI Radiopharmacy and Chemistry
Background Carbonic Anhydrase IX (CAIX) is a zinc metalloenzyme that is over-expressed in many cancers making it a valid target for targeted diagnostic imaging with Positron Emission Tomography (PET).
Asif Noor, Emily R. McGowan, Jessica K. Van Zuylekom, Carleen Cullinane, Peter D. Roselt, Rodney J. Hicks, Michael P. Wheatcroft, Paul S. Donnelly   +7 more
doaj   +1 more source

Synthesis and conformational studies of peptido-squaramide foldable modules: a new class of turn-mimetic compounds. [PDF]

[eng] The β-turn unit is one of the most important secondary structure elements in proteins. The access to new conformationally controlled foldable modules can afford compounds with interesting bioactivities.
Costa, A., Martínez, L., Sampedro, A., Rotger, C., Sanna, E.   +4 more
core   +1 more source

Grafted squaramide monoamine nanoparticles as simple systems for sulfate recognition in pure water

, 2012
New simple systems formed by a chain containing a squaramide function and a quaternised amine group attached to boehmite or silica-coated boehmite nanoparticles are able to discriminate anions in pure water.MCINN por un contrato ...
Costa, A., Piña, M.N., Garcia-España Monsonis, Enrique, Delgado-Pinar, E., Jiménez, H.R., Rotger, C., Alarcón, J.   +6 more
core   +1 more source

Two Squaramide-Based Fluorescent Probes for Cu2+ and Cd2+

Journal of Fluorescence
Abstract The development of potential toxic metal ion probes is of great significance in the field of environmental detection. Herein, two squaramide ligands (2a, 2b) were constructed by combining the characteristics of squaric acid and imine groups.
Yuanwei, Li, Hongxu, Wang, Qian, Tao, Bin, Wang   +3 more
openaire   +2 more sources

Cinchona‐Based Hydrogen‐Bond Donor Organocatalyst Metal Complexes: Asymmetric Catalysis and Structure Determination

ChemistryOpen
In this study, we describe the synthesis of cinchona (thio)squaramide and a novel cinchona thiourea organocatalyst. These catalysts were employed in pharmaceutically relevant catalytic asymmetric reactions, such as Michael, Friedel–Crafts, and A3 ...
Dr. Sándor Nagy, Dóra Richter, Gyula Dargó, Balázs Orbán, Gergő Gémes, Dr. Tibor Höltzl, Zsófia Garádi, Zsuzsanna Fehér, Dr. József Kupai   +8 more
doaj   +1 more source

Stereoselective [4+3]-Cycloaddition of 2-Amino-β-nitrostyrenes with Azaoxyallyl Cations to Access Functionalized 1,4-Benzodiazepin-3-ones

Molecules
The 1,4-benzodiazepine structural framework is a fascinating element commonly found in biologically active and pharmaceutically relevant compounds.
Yoseop Kim, Sung-Gon Kim
doaj   +1 more source

Chiral Squaramide-Functionalized Imidazolium-Based Organic–Inorganic Hybrid Silica Promotes Asymmetric Michael Addition of 1,3-Dicarbonyls to Nitroalkenes in Brine

, 2016
Chiral cinchona-based squaramide-functionalized organic–inorganic hybrid silica is developed through postgrafting 3-mercaptopropyltrimethoxylsilane onto imidazolium-based organic–inorganic hybrid silica, followed by the anchor of a squaramide ...
Guohua Liu (506590), Xiangming Xu (420946), Tanyu Cheng (1508341), Xiaochen Liu (356802), Ronghua Jin (510825), Jianyou Xu (1725223)   +5 more
core   +1 more source

Biological activity-informed synthesis of quinoline-derived chiral γ-nitroketones via a bifunctional squaramide

Heterocyclic Communications
Chiral γ-nitroketone-derived pyrrolidine N-oxide (III) exhibited potent in vitro anti-tumor activity against three cancer cell lines: human breast carcinoma (MDA-MB-231), human colorectal carcinoma (SW-480), and murine colorectal carcinoma (CT-26), with ...
Zhang Zhen-Wei, Huang Ruo-Chen, Xie Yu-Hang, Li Li-Zhen, Deng Yan-Qiu   +4 more
doaj   +1 more source