SRY mediates male-specific susceptibility to acute liver injury [PDF]
Cell Communication and SignalingBackground and aims Sex-determining region on the Y chromosome (SRY), a male-specific gene, can promote the development of various liver diseases including liver fibrosis, hepatocellular carcinoma.
Meng-yun Ke +9 more
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BMC Medical Genetics, 2010 Background Sex determining factor (SRY) located on the short arm of the Y chromosome, plays an important role in initiating male sex determination, resulting in development of testicular tissue.
Batra Swaraj +6 more
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Y-chromosome polymorphisms in 12 native, karagül, karacabey merino breeds from turkey and anatolian mouflon (ovis gmelinii anatolica) [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018 In this study, 182 male animals from 12 native sheep breeds, as well as Karacabey Merino and Karagül breeds of Anatolia, wild sheep Anatolian Mouflon (Ovis gmelinii anatolica) were used as the study material.
Arif PARMAKSIZ +7 more
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EVALUATION OF SEMEN SEX RATIO IN COOLED AND FROZEN SEMEN STRAWS BY REAL-TIME PCR [PDF]
Basrah Journal of Veterinary Research, 2016 The study was demonstrated on quantitative evaluation of SRY and ZFX gene of (120) semenstraws from 10 Holliston bull (60) straws in cooling state 5C° and 60 straws after deep freezingin liquid nitrogen) .
Baqer Ja’fer. Hassan +2 more
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Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression. [PDF]
PLoS ONE, 2012 SRY is a sex-determining gene that encodes a transcription factor, which triggers male development in most mammals. The molecular mechanism of SRY action in testis determination is, however, poorly understood.
Zhen Xu +11 more
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Gene expression and functional abnormalities in XX/Sry Leydig cells
Scientific Reports, 2021 The SRY gene induces testis development even in XX individuals. However, XX/Sry testes fail to produce mature sperm, due to the absence of Y chromosome carrying genes essential for spermatogenesis.
Shogo Yanai +10 more
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Frontiers in Neuroscience, 2021 Fetal alcohol exposure (FAE) causes various neurodevelopmental deficits in offspring, including reduced expression of the stress regulatory proopiomelanocortin (Pomc) gene and an elevated stress response for multiple generations via the male germline ...
Omkaram Gangisetty +2 more
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A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis. [PDF]
PLoS ONE, 2016 SRY-mutation-caused sex reversal is a rare disease and mostly associated with a de novo mutation since the patients with defective SRY is infertile. There are many reports about SRY-mutation associated 46, XY ovarian disorder of sex development (DSD ...
Wufang Fan +8 more
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OR15-5 Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program [PDF]
, 2019 A paradox is posed by metazoan gene-regulatory networks (GRNs) that are robust yet evolvable. Insight may be obtained through studies of bistable genetic circuits mediating developmental decisions. A model in organogenesis is provided by the sex-specific
Chen, Yen-Shan +3 more
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Sex determination in mythology and history [PDF]
, 2005 The history of ideas on how the sexes became divided spans at least three thousand years. The biblical account of the origin of Eve, and the opinions of the philosophers of classical Greece, have unexpected bearings on present-day ideas.
Mittwoch, U
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