Results 61 to 70 of about 66,303 (280)
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Frontiers in MicrobiologySingle-stranded DNA (ssDNA) is an essential intermediate of genome duplication but can also arise in the genome, including at highly transcribed loci. Although the origin recognition complex (ORC), a eukaryotic replication initiator, has been reported to
Hironori Kawakami +8 more
doaj +1 more source
PLoS ONE, 2023 Human Replication Protein A (hRPA) is a multidomain protein that interacts with ssDNA intermediates to provide the latter much-needed stability during DNA metabolism and maintain genomic integrity.
Sangeeta, Arnab Bhattacherjee
doaj
Coordinated Binding of Single-Stranded and Double-Stranded DNA by UvsX Recombinase. [PDF]
PLoS ONE, 2013 Homologous recombination is important for the error-free repair of DNA double-strand breaks and for replication fork restart. Recombinases of the RecA/Rad51 family perform the central catalytic role in this process.
Robyn L Maher, Scott W Morrical
doaj +1 more source
TheBorrelia burgdorferitelomere resolvase, ResT, anneals ssDNA complexed with its cognate ssDNA-binding protein [PDF]
Nucleic Acids Research, 2016 Spirochetes of the genus Borrelia possess unusual genomes that consist in a linear chromosome and multiple linear and circular plasmids. The linear replicons are terminated by covalently closed hairpin ends, referred to as hairpin telomeres. The hairpin telomeres represent a simple solution to the end-replication problem.
Huang, Shu Hui, Kobryn, Kerri
openaire +2 more sources
Advanced Functional Materials, EarlyView.DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen +3 more
wiley +1 more source
Covalent Functionalization of 2D Semiconductors: A Roadmap to Advanced Electronic Devices
Advanced Functional Materials, EarlyView.This Review presents recent advances in the covalent functionalization strategies for two‐dimensional semiconductors and their implementation in modern technologies. Layered materials are modified through diverse molecular chemistries (e.g., thiols, diazonium salts, alkyl halides, and electron‐deficient species) to tailor their surface properties ...
Ramiro Quirós‐Ovies +2 more
wiley +1 more source
Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis. [PDF]
PLoS Genetics, 2012 Antibody diversification necessitates targeted mutation of regions within the immunoglobulin locus by activation-induced cytidine deaminase (AID). While AID is known to act on single-stranded DNA (ssDNA), the source, structure, and distribution of these ...
Jahan-Yar Parsa +8 more
doaj +1 more source
eLife, 2023 Cells have evolved the DNA damage response (DDR) pathways in response to DNA replication stress or DNA damage. In the ATR-Chk1 DDR pathway, it has been proposed that ATR is recruited to RPA-coated single-stranded DNA (ssDNA) by direct ATRIP-RPA ...
Yunfeng Lin +5 more
doaj +1 more source
Quantification of ssDNA by ssDNA-Qubit and dsDNA-Qubit.
, 2016 Frozen-R1 and Trizol-h3 diluted with TE buffer or distilled water in 20 ng/μl were measured with ssDNA-Qubit and dsDNA-Qubit. The amounts of dsDNA (black) and ssDNA (white) were determined using the standard curve shown in S1 Fig.
Naoki Einaga (2551768) +3 more
core +1 more source