Results 141 to 150 of about 5,477 (176)

Pleural Effusion IL-33/sST2 Levels and Effects of Low and High IL-33/sST2 Levels on Human Mesothelial Cell Adhesion and Migration

Inflammation, 2019
Interleukin 33 (IL-33) is an alarmin with multiple roles in immunity and cell homeostasis, highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). Production of IL-33 and soluble ST2 (sST2), a decoy receptor for IL-33, has been implicated in several pulmonary diseases, but both have been scarcely investigated ...
Ourania S Kotsiou, Jagirdar Rm, Konstantinos I Gourgoulianis   +2 more
exaly   +3 more sources

Characterisation of somatostatin sst2 receptor splice variants

Journal of Physiology-Paris, 2000
Somatostatin is a peptide with a multitude of functions in the central nervous system and the periphery. It mediates its actions by binding to high-affinity G-protein coupled receptors, genes for five of which (sst1-sst5) have recently been cloned. The somatostatin sst2 receptor exists as two splice variants, sst2(a) and sst2(b) receptors, which differ
S L, Cole, M, Schindler
openaire   +2 more sources

IL33 and sST2 serum level in systemic sclerosis microvascular involvement

Microvascular Research, 2022
Endothelial dysfunction and microvascular damage are hallmarks of systemic sclerosis (SSc). Objective of this study was to evaluate IL33 and ST2 serum levels in SSc patients and healthy controls (HC). Secondary aim was to evaluate the IL33 axis in the SSc microvascular manifestation.IL33 and sST2 have been assessed in 46 SSc patients and 24 HC matched ...
Pellicano C., Iannazzo F., Romaggioli L., Rosato E.   +3 more
openaire   +3 more sources

Phosphorylation of the RGS Protein Sst2 by the MAP Kinase Fus3 and Use of Sst2 as a Model To Analyze Determinants of Substrate Sequence Specificity

Biochemistry, 2005
Previously, we used mass spectrometry to demonstrate pheromone-stimulated phosphorylation of Ser-539 in Sst2, a regulator of G protein signaling in yeast Saccharomyces cerevisiae [Garrison, T. R., et al. (1999) J. Biol. Chem. 274, 36387-36391]. Here, we show that Sst2 phosphorylation is mediated by the mitogen-activated protein (MAP) kinase Fus3 ...
Stephen C, Parnell, Louis A, Marotti, Lee, Kiang, Matthew P, Torres, Christoph H, Borchers, Henrik G, Dohlman   +5 more
openaire   +2 more sources

Presence of sst2(a) receptor immunoreactivity in rat ependyma and tanycytes

Neuroreport, 2001
Somatostatin sst2(a) receptor was observed, by immunofluorescence, in ependymal cells and in tanycytes of the wall of the ventricle and the hypothalamic recess of the male rat median eminence. Strong immunoreactivity for the receptor protein was observed in lateral tanycytes (alpha-type) while a moderate signal was seen in medial tanycytes (beta-type).
S H, Hashemi, J Y, Li, M, Schindler, A, Dahlström   +3 more
openaire   +2 more sources

The impact of SST2 trafficking and signaling in the treatment of pancreatic neuroendocrine tumors

Molecular and Cellular Endocrinology, 2021
Pancreatic neuroendocrine tumors (Pan-NETs), are heterogeneous neoplasms, whose incidence and prevalence are increasing worldwide. Pan-NETs are characterized by the expression of somatostatin receptors (SSTs). In particular, SST2 is the most widely distributed SST in NETs, thus representing the main molecular target for somatostatin analogs (SSAs ...
E, Vitali, S, Piccini, G, Trivellin, V, Smiroldo, E, Lavezzi, A, Zerbi, G, Pepe, A G, Lania   +7 more
openaire   +2 more sources

Anxiolytic and antidepressant actions of somatostatin: the role of sst2 and sst3 receptors

Psychopharmacology, 2009
Somatostatin is a cyclic polypeptide that inhibits the release of a variety of regulatory hormones (e.g., growth hormone, insulin, glucagon, and thyrotropin). Somatostatin is also widely distributed within the central nervous system (CNS), acting both as a neurotransmitter and as a neuromodulator. Recently, we showed that intracerebroventricular (i.c.v.
Elif, Engin, Dallas, Treit
openaire   +2 more sources

Localization and pharmacological characterization of somatostatin sst2 sites in the rat cerebellum

Naunyn-Schmiedeberg's Archives of Pharmacology, 1995
Radioligand binding studies were performed in membranes of rat cerebellum using [125I]-[Tyr3]octreotide ([125I]204-090) to characterize the nature of cerebellar somatostatin receptors. Saturation experiments suggest the presence of a single class of binding sites with high affinity, pKd = 9.53 +/- 0.11, but low receptor density, Bmax = 12.7 +/- 1.0 ...
C, Piwko, V S, Thoss, D, Hoyer
openaire   +2 more sources

Presence of somatostatin sst2 receptors in the developing rat auditory system

Developmental Brain Research, 1996
A transient expression of somatostatin mRNA as well as of the peptide itself has been described in the developing mammalian auditory brainstem. However, little is known about the presence, and the spatial and temporal pattern of somatostatin (SRIF) receptor subtypes in this system.
V S, Thoss, M, Kungel, E, Friauf, D, Hoyer   +3 more
openaire   +2 more sources

Somatostatin receptors (sst2) regulate cGMP production in rat retina

Regulatory Peptides, 2006
The present study investigated the effect of somatostatin in the regulation of cGMP levels in rat retina and the mechanisms involved in this process. Isolated rat retinas were treated alone or in the presence of somatostatin (0.01-10 microM), BIM23014 (sst2 agonist, 0.01-10 microM), L-796,778 (sst3 agonist, 10 microM), somatostatin (0.1 microM) in ...
Niki, Mastrodimou, Foteini, Kiagiadaki, Mira, Hodjarova, Efthimia, Karagianni, Kyriaki, Thermos   +4 more
openaire   +2 more sources