Results 171 to 180 of about 8,618 (210)

3-Thio-1,2,4-triazoles, novel somatostatin sst2/sst5 agonists

Bioorganic & Medicinal Chemistry Letters, 2005
Novel 3-thio-1,2,4-triazoles have been obtained via a solution-phase parallel synthesis strategy, affording potent non-peptidic human somatostatin receptor subtypes 2 and 5 agonists.
Marie-Odile, Contour-Galcéra, Alban, Sidhu, Pascale, Plas, Pierre, Roubert   +3 more
openaire   +2 more sources

Somatostatin receptors (sst2) regulate cGMP production in rat retina

Regulatory Peptides, 2006
The present study investigated the effect of somatostatin in the regulation of cGMP levels in rat retina and the mechanisms involved in this process. Isolated rat retinas were treated alone or in the presence of somatostatin (0.01-10 microM), BIM23014 (sst2 agonist, 0.01-10 microM), L-796,778 (sst3 agonist, 10 microM), somatostatin (0.1 microM) in ...
Niki, Mastrodimou, Foteini, Kiagiadaki, Mira, Hodjarova, Efthimia, Karagianni, Kyriaki, Thermos   +4 more
openaire   +2 more sources

Interleukin-33/sST2: Dynamic assessment in patients with acute coronary syndrome

Advances in Medical Sciences, 2023
Interleukin (IL)-33 and its soluble receptor ST2 (sST2) play a crucial role in the immune response. sST2 has been approved by the Food and Drug Administration as a prognostic biomarker of mortality in chronic heart failure patients, however, the role of IL-33 and sST2 in atherosclerotic cardiovascular disease remains unclear.
Anna Witkowska, Mateusz Staciwa, Iwona Duraj, Ewelina Wozniak, Marlena Broncel, Paulina Gorzelak-Pabis   +5 more
openaire   +2 more sources

sST2 and Galectin-3 genotyping in patients with persistent atrial fibrillation

Molecular Biology Reports, 2021
Genotyping of ST2 and galectin-3 in atrial fibrillation (AF) is not well analyzed. The aim of our study was to analyze the possible relationship between levels of sST2 and galectin-3 and three polymorphisms in patients with AF. We included 125 patients with persistent AF undergoing electric cardioversion.
Ruth Saez-Maleta, Ana Merino-Merino, Simon Gundin-Menendez, Ricardo Salgado-Aranda, Daniel AlKassam-Martinez, Virginia Pascual-Tejerina, Javier Martin-Gonzalez, Javier Garcia-Fernandez, Jose-Angel Perez-Rivera   +8 more
openaire   +2 more sources

Dosage du récepteur soluble sST2 : perspectives

Revue Francophone des Laboratoires, 2017
Resume L’insuffisance cardiaque (IC) est un probleme majeur pour nos societes contemporaines tant en termes de prevalence, de mortalite et de cout. Les peptides natriuretiques sont des biomarqueurs reconnus pour l’aide au diagnostic d’IC mais aussi pour la stratification du risque des patients.
openaire   +1 more source

Role of Sst2 in Modulating G Protein-Coupled Receptor Signaling

Biochemical and Biophysical Research Communications, 1996
Sst2 formally acts as an inhibitor of G protein-coupled receptor signaling in yeast perhaps stabilizing a G protein/unactivated receptor complex. desTrp1,Ala3 alpha-factor (dTA-alpha f), normally a competitive antagonist, activated responses in an sst2 strain.
A, Shah, L, Marsh
openaire   +2 more sources

Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension

Biomarkers, 2020
Purpose This study examined sST2, GDF-15, and galectin-3 as indicators of disease severity and therapy response in chronic thromboembolic pulmonary hypertension (CTEPH).
S. Kriechbaum, C. Wiedenroth, K. Peters, Marta A. Barde, Ruth Ajnwojner, J. Wolter, M. Haas, F. Roller, S. Guth, A. Rieth, A. Rolf, C. Hamm, E. Mayer, T. Keller, C. Liebetrau   +14 more
semanticscholar   +1 more source

The impact of SST2 trafficking and signaling in the treatment of pancreatic neuroendocrine tumors.

Molecular and Cellular Endocrinology, 2021
Pancreatic neuroendocrine tumors (Pan-NETs), are heterogeneous neoplasms, whose incidence and prevalence are increasing worldwide. Pan-NETs are characterized by the expression of somatostatin receptors (SSTs).
E. Vitali, S. Piccini, G. Trivellin, V. Smiroldo, E. Lavezzi, A. Zerbi, G. Pepe, A. Lania   +7 more
semanticscholar   +1 more source

Soluble ST2 (sST2) as potential marker for hepatic cystic echinococcosis activity

Journal of Infection, 2020
this study aims to identify the potential marker for hepatic cystic echinococcosis (CE) activity.totally 97 CE patients and 47 health control (HC) subjects were included. Based on the ultrasound (US) images, CE patients were further categorized as active CE (ACE; 52 cases) and inactive CE (IACE; 45 cases).
Mengting, An, Yuejie, Zhu, Cheng, Xu, Yujiao, Li, Nannan, Pang, Xiao, Zhao, Zhiwei, Li, Hongying, Wang, Fengbo, Zhang, Jianbing, Ding   +9 more
openaire   +2 more sources

Pleural Effusion IL-33/sST2 Levels and Effects of Low and High IL-33/sST2 Levels on Human Mesothelial Cell Adhesion and Migration

Inflammation, 2019
Interleukin 33 (IL-33) is an alarmin with multiple roles in immunity and cell homeostasis, highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). Production of IL-33 and soluble ST2 (sST2), a decoy receptor for IL-33, has been implicated in several pulmonary diseases, but both have been scarcely investigated ...
Ourania S, Kotsiou, Rajesh M, Jagirdar, Eleftherios D, Papazoglou, Chrissi, Hatzoglou, Konstantinos I, Gourgoulianis, Sotirios G, Zarogiannis   +5 more
openaire   +2 more sources