Results 41 to 50 of about 11,857 (246)

Study of self-oscillations of a distributed rotor from a material with hereditarily elastic properties

Partial Differential Equations in Applied Mathematics
Self-oscillatory solutions of dynamic equations of transverse vibrations of a distributed rotating ideally balanced rotor (shaft) on an isotropic support made of a material with nonlinear hereditary properties are studied.
E.P. Kubyshkin
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

On Coupled p-Laplacian Fractional Differential Equations with Nonlinear Boundary Conditions

Complexity, 2017
This paper is related to the existence and uniqueness of solutions to a coupled system of fractional differential equations (FDEs) with nonlinear p-Laplacian operator by using fractional integral boundary conditions with nonlinear term and also to ...
Aziz Khan, Yongjin Li, Kamal Shah, Tahir Saeed Khan   +3 more
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An encounter in the realm of Structural Stability between a qualitative theory for geometric shapes and one for the integral foliations of differential equations

, 2020
This evocative essay focuses on some landmarks that led the author to the study of principal curvature configurations on surfaces in $\mathbb R^3$, their structural stability and generic properties. The starting point was an encounter with the book of D. Struik and the reading of the references to the works of Euler, Monge and Darboux found there.
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Finite Difference Method for Solving Partial Integro-Differential Equations

پژوهش‌های ریاضی, 2020
Introduction In this paper, we have introduced a new method for solving a class of the partial integro-differential equation with the singular kernel by using the finite difference method.
Majid Erfanian, Hamed Zeidabadi
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Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Elastoplastic stability of thin rectangular plates under complex and impure loading

Vietnam Journal of Mechanics, 2001
This paper deals with investigation of the elastoplastic stability of thin rectangular plates. The plate considered herein is subjected to the biaxial compressive forces which are assumed to be linearly distributed along every its edge.
Vu Cong Ham
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