Results 41 to 50 of about 341,746 (252)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Advances in Difference Equations, 2018 This paper is devoted to establishing the existence theory for at least one solution to a coupled system of fractional order differential equations (FDEs).
Kamal Shah +3 more
doaj +1 more source
Gaussian estimates for a heat equation on a network
, 2007 We consider a diffusion problem on a network on whose nodes we impose Dirichlet and generalized, non-local Kirchhoff-type conditions. We prove well-posedness of the associated initial value problem, and we exploit the theory of sub-Markovian and ...
Mugnolo, Delio
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The use of discrete orthogonal projections in boundary element methods [PDF]
, 2000 In recent papers by Sloan and Wendland Grigorie and Sloan and Grigorie Sloan and Brandts a formalismwas developed that serves many important and interesting applications in boundary element methods the commutator property for splines Based on ...
Brandts, J.
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
On eigenfunction expansion of solutions to the Hamilton equations
, 2013 We establish a spectral representation for solutions to linear Hamilton equations with positive definite energy in a Hilbert space. Our approach is a special version of M.
Komech, Alexander, Kopylova, Elena
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Quantization of chiral antisymmetric tensor fields
, 2005 Chiral antisymmetric tensor fields can have chiral couplings to quarks and leptons. Their kinetic terms do not mix different representations of the Lorentz symmetry and a local mass term is forbidden by symmetry.
C. WETTERICH, Ogievetsky V. I.
core +4 more sources