Results 51 to 60 of about 83,271,276 (264)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Existence and stability of solution for a coupled system of Caputo–Hadamard fractional differential equations

Fixed Point Theory and Algorithms for Sciences and Engineering
In our present work, we study a coupled system of Caputo–Hadamard fractional differential equations supplemented with a novel set of initial value conditions involving the η = ( t d d t ) $\eta =(t\frac{d}{dt})$ derivatives.
Mesfin Teshome Beyene, Mitiku Daba Firdi, Tamirat Temesgen Dufera   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Study of self-oscillations of a distributed rotor from a material with hereditarily elastic properties

Partial Differential Equations in Applied Mathematics
Self-oscillatory solutions of dynamic equations of transverse vibrations of a distributed rotating ideally balanced rotor (shaft) on an isotropic support made of a material with nonlinear hereditary properties are studied.
E.P. Kubyshkin
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

An encounter in the realm of Structural Stability between a qualitative theory for geometric shapes and one for the integral foliations of differential equations

, 2020
This evocative essay focuses on some landmarks that led the author to the study of principal curvature configurations on surfaces in $\mathbb R^3$, their structural stability and generic properties. The starting point was an encounter with the book of D. Struik and the reading of the references to the works of Euler, Monge and Darboux found there.
openaire   +2 more sources

Analysis of direct segregated boundary-domain integral equations for variable-coefficient mixed bvps in exterior domains [PDF]

, 2013
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2013 World Scientific Publishing.Direct segregated systems of boundary-domain integral equations are formulated for the mixed (
Mikhailov, SE, Natroshvili, D, Chkadua, O   +2 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Analysis of segregated boundary-domain integral equations for variable-coefficient problems with cracks [PDF]

, 2010
This is the pre-print version of the article. The official published version can be obtained from the link below - Copyright @ 2011 Wiley-BlackwellSegregated direct boundary-domain integral equation (BDIE) systems associated with mixed, Dirichlet and ...
S.E. Mikhailov, Mikhailov, SE, O. Chkadua, Natroshvili, D, Chkadua, O, D. Natroshvili   +5 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source