Results 51 to 60 of about 341,444 (262)

On eigenfunction expansion of solutions to the Hamilton equations

, 2013
We establish a spectral representation for solutions to linear Hamilton equations with positive definite energy in a Hilbert space. Our approach is a special version of M.
Komech, Alexander, Kopylova, Elena
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Existence and stability of solution for a coupled system of Caputo–Hadamard fractional differential equations

Fixed Point Theory and Algorithms for Sciences and Engineering
In our present work, we study a coupled system of Caputo–Hadamard fractional differential equations supplemented with a novel set of initial value conditions involving the η = ( t d d t ) $\eta =(t\frac{d}{dt})$ derivatives.
Mesfin Teshome Beyene, Mitiku Daba Firdi, Tamirat Temesgen Dufera   +2 more
doaj   +1 more source

Comments on the Spectrum of CHL Dyons [PDF]

, 2007
We address a number of puzzles relating to the proposed formulae for the degeneracies of dyons in orbifold compactifications of the heterotic string to four dimensions with $N =4$ supersymmetry. The partition function for these dyons is given in terms of
Dabholkar, Atish, Gaiotto, Davide, Nampuri, Suresh   +2 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Investigation of multi-term delay fractional differential equations with integro-multipoint boundary conditions

AIMS Mathematics
A new class of nonlocal boundary value problems consisting of multi-term delay fractional differential equations and multipoint-integral boundary conditions is studied in this paper.
Najla Alghamdi, Bashir Ahmad, Esraa Abed Alharbi, Wafa Shammakh   +3 more
doaj   +1 more source

Stable multilevel splittings of boundary edge element spaces [PDF]

, 2018
We establish the stability of nodal multilevel decompositions of lowest-order conforming boundary element subspaces of the trace space ${\boldsymbol{H}}^{-\frac {1}{2}}(\operatorname {div}_{\varGamma },{\varGamma })$ of ${\boldsymbol{H}}(\operatorname ...
Hiptmair, Ralf, Mao, Shipeng
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Study of self-oscillations of a distributed rotor from a material with hereditarily elastic properties

Partial Differential Equations in Applied Mathematics
Self-oscillatory solutions of dynamic equations of transverse vibrations of a distributed rotating ideally balanced rotor (shaft) on an isotropic support made of a material with nonlinear hereditary properties are studied.
E.P. Kubyshkin
doaj   +1 more source