Results 61 to 70 of about 170,356,237 (303)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Asymptotic Stabilization of Delayed Linear Fractional-Order Systems Subject to State and Control Constraints

Fractal and Fractional, 2022
Studies have shown that fractional calculus can describe and characterize a practical system satisfactorily. Therefore, the stabilization of fractional-order systems is of great significance.
Xindong Si, Zhen Wang, Zhibao Song, Ziye Zhang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A new switching strategy for exponential stabilization of uncertain discrete-time switched linear systems in guaranteed cost control problem

Iranian Journal of Electrical and Electronic Engineering, 2015
Uncertain switched linear systems are known as an important class of control systems. Performance of these systems is affected by uncertainties and its stabilization is a main concern of recent studies.
M. R. Ramezani-al, A. Vahidian Kamyad, N. Pariz   +2 more
doaj  

Robust stabilization of hybrid uncertain stochastic systems with time-varying delay by discrete-time feedback control

Advances in Difference Equations, 2017
This paper is concerned with the robust stabilization problem for a class of continuous-time hybrid uncertain stochastic systems with time-varying delay.
Yuyuan Li, Chunhai Kou
doaj   +1 more source

Finite-Time Simultaneous Stabilization for Stochastic Port-Controlled Hamiltonian Systems over Delayed and Fading Channels

Complexity, 2020
In this paper, a finite-time simultaneous stabilization problem is investigated for a set of stochastic port-controlled Hamiltonian (PCH) systems over delayed and fading noisy channels. The feedback control signals transmitted via a communication network
Yaping Tang, Weiwei Sun, Dongqing Liu
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An optimal gains matrix for time-delay feedback control [PDF]

, 2009
In this paper we propose an optimal time-delayed feedback control (TDFC) for tracking unstable periodic orbits (UPOs). It is shown that TDFC will drive a trajectory onto a periodic orbit while minimising an integral of a cost function of the error in ...
Biggs, James, Biggs, J.D., BIGGS, JAMES DOUGLAS, James Biggs, Colin R.McInnes, McInnes, Colin R., McInnes, C.R.   +6 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Stabilization of Chaotic Systems With Both Uncertainty and Disturbance by the UDE-Based Control Method

IEEE Access, 2020
This paper investigates the stabilization of a class of chaotic systems with both model uncertainty and external disturbance. By combining the dynamic feedback control method, and the uncertainty and disturbance estimator (UDE)-based control method, a ...
Xiaofeng Yi, Rongwei Guo, Yi Qi
doaj   +1 more source