Results 61 to 70 of about 226,393 (341)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Robust stabilization of hybrid uncertain stochastic systems with time-varying delay by discrete-time feedback control

Advances in Difference Equations, 2017
This paper is concerned with the robust stabilization problem for a class of continuous-time hybrid uncertain stochastic systems with time-varying delay.
Yuyuan Li, Chunhai Kou
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Stabilization of Chaotic Systems With Both Uncertainty and Disturbance by the UDE-Based Control Method

IEEE Access, 2020
This paper investigates the stabilization of a class of chaotic systems with both model uncertainty and external disturbance. By combining the dynamic feedback control method, and the uncertainty and disturbance estimator (UDE)-based control method, a ...
Xiaofeng Yi, Rongwei Guo, Yi Qi
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A new switching strategy for exponential stabilization of uncertain discrete-time switched linear systems in guaranteed cost control problem

Iranian Journal of Electrical and Electronic Engineering, 2015
Uncertain switched linear systems are known as an important class of control systems. Performance of these systems is affected by uncertainties and its stabilization is a main concern of recent studies.
M. R. Ramezani-al, A. Vahidian Kamyad, N. Pariz   +2 more
doaj  

Stabilization of Coupled Linear Systems Via Bounded Distributed Feedbacks

Известия Иркутского государственного университета: Серия "Математика", 2019
This article deals with a stabilization problem for a team of linear interconnected systems via bounded feedbacks. Effective approaches to stabilization of constrained systems from model predictive control theory are developed for the decentralized case ...
N. M. Dmitruk
doaj   +1 more source

Robust and Resilient Finite-time Bounded Control of Discrete-time Uncertain Nonlinear Systems [PDF]

, 2013
Finite-time state-feedback stabilization is addressed for a class of discrete-time nonlinear systems with conic-type nonlinearities, bounded feedback control gain perturbations, and additive disturbances.
ElBsat, Mohammad N., Yaz, Edwin E
core   +1 more source

On stabilization of nonlinear systems with drift by time-varying feedback laws

, 2019
This paper deals with the stabilization problem for nonlinear control-affine systems with the use of oscillating feedback controls. We assume that the local controllability around the origin is guaranteed by the rank condition with Lie brackets of length
Grushkovskaya, Victoria, Zuyev, Alexander   +1 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source