Results 61 to 70 of about 46,630 (268)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Stabilization of Chaotic Systems With Both Uncertainty and Disturbance by the UDE-Based Control Method

IEEE Access, 2020
This paper investigates the stabilization of a class of chaotic systems with both model uncertainty and external disturbance. By combining the dynamic feedback control method, and the uncertainty and disturbance estimator (UDE)-based control method, a ...
Xiaofeng Yi, Rongwei Guo, Yi Qi
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The fast flight stabilization strategy in flying insects

Theoretical and Applied Mechanics Letters
Flying insects demonstrate remarkable control over their body movements and orientation, enabling them to perform rapid maneuvers and withstand external disturbances in just a few wing beats.
Xuefei Cai, Hao Liu
doaj   +1 more source

Stabilization of Coupled Linear Systems Via Bounded Distributed Feedbacks

Известия Иркутского государственного университета: Серия "Математика", 2019
This article deals with a stabilization problem for a team of linear interconnected systems via bounded feedbacks. Effective approaches to stabilization of constrained systems from model predictive control theory are developed for the decentralized case ...
N. M. Dmitruk
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Reverse quantum state engineering using electronic feedback loops

New Journal of Physics, 2012
We propose an all-electronic technique to manipulate and control interacting quantum systems by unitary single-jump feedback conditioned on the outcome of a capacitively coupled electrometer and, in particular, a single-electron transistor.
Gerold Kießlich, Clive Emary, Gernot Schaller, Tobias Brandes   +3 more
doaj   +1 more source

Stabilization of a class of fractional-order nonautonomous systems using quadratic Lyapunov functions

Advances in Difference Equations, 2018
In this paper, we aim to solve the stabilization problem for a large class of fractional-order nonautonomous systems via linear state feedback control and adaptive control.
Quan Xu, Shengxian Zhuang, Xiaohui Xu, Chang Che, Yankun Xia   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

On Stabilization of Linear Switched Singular Systems via P-D State Feedback

IEEE Access, 2020
Impulsive phenomenon and state jumps at switching instants are inevitable control difficulties in the study of stability for switched singular systems. Proportional-derivative (P-D) state feedback may be an effective way to eliminate impulsive behaviors ...
Zairui Gao, Yunlong Liu, Ziyun Wang
doaj   +1 more source