Results 51 to 60 of about 69,372 (313)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

To "stabilize'' or not to "stabilize"?

open access: yes, 2002
The controversial question of whether or not an atom will be completely ionized by a laser pulse of arbitrarily increasing intensity is discussed.
Geltman, S., Fotino, M.
openaire   +2 more sources

Providing Stability to High Internal Phase Emulsion Gels Using Brewery Industry By-Products as Stabilizers

open access: yesGels, 2021
The modern brewing industry generates high amounts of solid wastes containing biopolymers—proteins and polysaccharides—with interesting technological and functional properties. The novelty of this study was to use raw by-product from the brewing industry
Adrián López-García   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Stability of Graphs [PDF]

open access: yesThe Electronic Journal of Combinatorics, 2009
Positively weighted graphs have a natural intrinsic metric. We consider finite, positively weighted graphs with a positive lower bound for their minimal weights and show that any two such graphs, which are close enough with respect to the Gromov-Hausdorff metric, are equivalent as graphs.
Bünyamin Demir, Ali Deniz, Sahin Koçak
openaire   +3 more sources

Influence of Stabilizer on the Development of Luteolin Nanosuspension for Cutaneous Delivery: An In Vitro and In Vivo Evaluation

open access: yesPharmaceutics, 2021
Luteolin is a natural drug used as an antioxidant and anti-inflammatory, but unfortunately, it possesses low water solubility, which hinders its delivery via the skin.
Mohammed Elmowafy   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Suspension stability of passion fruit nectar formulated with carboxymethyl cellulose: Analysis of sedimentation kinetics

open access: yesAgroindustrial Science
This study evaluated the suspension stability of passion fruit nectar formulated with different concentrations of carboxymethyl cellulose (CMC). Passion fruit nectars with 0, 0.02, 0.1 and 0.2% (w/v) CMC were placed at rest in test tubes at room ...
Jesús Noel-Cuya   +3 more
doaj   +1 more source

Milk ice cream composition and structure improvement [PDF]

open access: yesТехника и технология пищевых производств, 2018
The work reveals the results of the study devoted to milk ice cream composition improvement in order to meet the requirements for healthy foods (with satisfactory nutritional value) to the fullest extent and to obtain creamy consistency as well as high ...
Tvorogova A.   +3 more
doaj   +1 more source

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