Results 81 to 90 of about 145,542 (292)

Polymerizable ultraviolet stabilizers for outdoor use [PDF]

Polymeric materials that are stable enough to use outdoors without changes in excess of 20 years are investigated. Ultraviolet stabilizers or plastic materials were synthesized, polymerizable ultraviolet stabilizers, particularly of the 2(2-hydroxyphenyl)
Vogl, O.
core   +1 more source

Codes and Protocols for Distilling $T$, controlled-$S$, and Toffoli Gates

, 2018
We present several different codes and protocols to distill $T$, controlled-$S$, and Toffoli (or $CCZ$) gates. One construction is based on codes that generalize the triorthogonal codes, allowing any of these gates to be induced at the logical level by ...
Haah, Jeongwan, Hastings, Matthew B.
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques

Pharmaceutics
Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids.
Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Mahesh Attimarad, Anroop B. Nair   +4 more
doaj   +1 more source

Pengaruh Penggunaan Sukrosa dan Penstabil Karboksi Metil Selulosa (CMC) terhadap Mutu dan Gingerol Jahe Instan

JLI: Jurnal Litbang Industri, 2017
Ginger contains gingerol which is very useful in the pharmaceutical and food industries. Gingerol has an ability as an antioxidant and anti-inflammatory.
F Firdausni, Wilsa Hermianti, Robby Kumar   +2 more
doaj   +1 more source

Wonderful blowups associated to group actions

, 2000
A group action on a smooth variety provides it with the natural stratification by irreducible components of the fixed point sets of arbitrary subgroups.
Borisov, Lev A., Gunnells, Paul E.
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source