Results 211 to 220 of about 30,137 (254)

Stable Isotopic Labeling for Proteomics

2011
Since the coining of the term Proteome, the field of Proteomics has developed rapidly and come to rely heavily on mass spectrometry, initially for protein identification but recently the use of stable isotopic labels for protein quantitation has grown in importance.
Ashman, Keith, Ruppen Canas, Maria Isabel, Luque-Garcia, Jose L., Garcia Martinez, Fernando   +3 more
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Stable isotopic labelling of heterocyclic compounds

Journal of Labelled Compounds and Radiopharmaceuticals, 2007
AbstractStable isotopically labelled (SIL) versions of Glimepiride 1 (10 steps, 11% overall yield), a blood glucose lowering drug, and Melagatran 13 (9 steps, 17% overall yield), an anticoagulant with similar uses to warfarin, were synthesized as internal standards for LCMS assays. Modifications of known routes (Weyer et al., US Patent 4379785, Hocchst,
Andrew J. Burton, Alan H. Wadsworth
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Stable Isotope Labeling Methods in Protein Profiling

2013
Mass spectrometry (MS) analysis of peptides and proteins has evolved dramatically over the last 20 years. Improvement of MS instrumentation, computational data analysis, and the availability of complete sequence databases for many species have made large-scale proteomics analyses possible.
Lengqvist J, Sandberg A
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Benefits of stable isotope labeling in RNA analysis

Biological Chemistry, 2019
AbstractRNAs are key players in life as they connect the genetic code (DNA) with all cellular processes dominated by proteins. They contain a variety of chemical modifications and many RNAs fold into complex structures. Here, we review recent progress in the analysis of RNA modification and structure on the basis of stable isotope labeling techniques ...
Asadi-Atoi, Paria, Barraud, Pierre, Tisné, Carine, Kellner, Stefanie   +3 more
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Synthesis of carbon‐14 and stable isotope labeled Censavudine

Journal of Labelled Compounds and Radiopharmaceuticals, 2022
Censavudine is a nucleoside reverse transcriptase inhibitor (NRTI) explored clinically by Bristol Myers Squibb for the treatment of human immunodeficiency virus‐1 (HIV‐1). As part of the development process, a carbon‐14 labeled analog was synthesized for use in a human absorption, distribution, metabolism, and excretion (ADME) study.
Richard C. Burrell, Samuel J. Bonacorsi, Adrian Ortiz, Tamas Benkovics, Zhongping Shi   +4 more
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Synthesis of stable isotope labeled norepinephrine

Journal of Labelled Compounds, 1975
AbstractRacemic norepinephrine was synthesized with three deuterium atoms on the alkyl chain. The deuteration was accomplished by D/H exchange on the intermediate, dibenzylaminodihydroxyacetophenone, followed by reduction of the keto moiety and cleavage of the benzyl‐protecting groups with deuterium gas.
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Progress in stable isotope labeled quantitative proteomics methods

Chinese Journal of Chromatography, 2013
Quantitative proteomics is an important research field in post-genomics era. There are two strategies for proteome quantification: label-free methods and stable isotope labeling methods which have become the most important strategy for quantitative proteomics at present. In the past few years, a number of quantitative methods have been developed, which
Yuan, Zhou, Yichu, Shan, Lihua, Zhang, Yukui, Zhang   +3 more
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Synthesis of unlabelled and stable‐isotope–labelled glucuronide metabolites of dapagliflozin and synthesis of stable‐isotope–labelled dapagliflozin

Journal of Labelled Compounds and Radiopharmaceuticals, 2017
Two regioisomeric glucuronide metabolites of dapagliflozin (BMS‐512148) were synthesized and used to elucidate the structures of dapagliflozin metabolites observed in human urine samples. The structures of the synthetic metabolites were assigned by heteronuclear multiple‐bond correlation, ROESY, and total correlation spectroscopy experiments. Analogues
Kai, Cao, John A, Brailsford, Ming, Yao, Janet, Caceres-Cortes, Robert, Espina, Samuel J, Bonacorsi   +5 more
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Syntheses of three stable isotope‐labeled ethylcyclopropanes

Journal of Labelled Compounds and Radiopharmaceuticals, 2009
AbstractThree stable isotope‐labeled ethylcyclopropanes have been synthesized in preparation for a mechanistic study of its fragmentation to methane and butadiene. Two tactical innovations have been used to deal with practical synthetic challenges posed by the very limited solubility of methylmagnesium iodide in tetrahydrofuran and the high volatility ...
John E. Baldwin, Edward J. O'Neil
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Stable isotope labeling of sugars simplified

Chemical & Engineering News Archive, 1979
A new way to label sugar molecules with stable atomic isotopes in practically any position has been developed by biochemists at Michigan State University, East Lansing. Their contribution, part of a national program to exploit stable atomic isotopes, will help spread the use of methods, such as nuclear magnetic resonance spectroscopy and mass ...
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