Results 211 to 220 of about 30,977 (246)
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Stable isotope labeled alpha‐ketoacids
Journal of Labelled Compounds and Radiopharmaceuticals, 1984AbstractAlkylation of diethyl oxalpropionate with [D3]methyl iodide followed by acid hydrolysis led to 3‐[D3]methyl‐2‐oxobutyric (α‐ketoisovaleric) acid. Alkylation of N‐t‐butylpropylimine with [D3]methyl iodide followed by hydrolysis gave 2‐[D3]methylpropanal. This was further alkylated with 2,2‐difluoro‐1‐tosyloxyvinyllithium and hydrolyzed to afford
Sun‐Shine Yuan, Alfred M. Ajami
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Stable isotopic labelling of heterocyclic compounds
Journal of Labelled Compounds and Radiopharmaceuticals, 2007AbstractStable isotopically labelled (SIL) versions of Glimepiride 1 (10 steps, 11% overall yield), a blood glucose lowering drug, and Melagatran 13 (9 steps, 17% overall yield), an anticoagulant with similar uses to warfarin, were synthesized as internal standards for LCMS assays. Modifications of known routes (Weyer et al., US Patent 4379785, Hocchst,
Andrew J. Burton, Alan H. Wadsworth
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Stable Isotope Labeling Methods in Protein Profiling
2013Mass spectrometry (MS) analysis of peptides and proteins has evolved dramatically over the last 20 years. Improvement of MS instrumentation, computational data analysis, and the availability of complete sequence databases for many species have made large-scale proteomics analyses possible.
Lengqvist J, Sandberg A
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Stable Isotopes Labeling of Drugs in Pediatric Clinical Pharmacology
Pediatrics, 1999Stable isotope labeling (SIL) still has not been used very much in pediatric and perinatal clinical pharmacology. However, this method has numerous advantages. It allows one to determine the concentration of drugs with great sensitivity, thereby allowing quantification in small amounts of biologic samples.
G, Pons, E, Rey
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Synthesis of stable isotope labeled norepinephrine
Journal of Labelled Compounds, 1975AbstractRacemic norepinephrine was synthesized with three deuterium atoms on the alkyl chain. The deuteration was accomplished by D/H exchange on the intermediate, dibenzylaminodihydroxyacetophenone, followed by reduction of the keto moiety and cleavage of the benzyl‐protecting groups with deuterium gas.
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The use of stable isotope labelling for the analytical chemistry of drugs
Drug Testing and Analysis, 2011This perspective reviews the potential for stable isotope labelling to examine the metabolic transformations of drugs. The increased sensitivity and widespread availability of modern nuclear magnetic resonance (NMR) and high‐resolution mass spectrometers will increase the application of stable isotopes to study drug metabolism.
Clifford J, Unkefer, Rodolfo A, Martinez
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Stable isotope labeling of sugars simplified
Chemical & Engineering News Archive, 1979A new way to label sugar molecules with stable atomic isotopes in practically any position has been developed by biochemists at Michigan State University, East Lansing. Their contribution, part of a national program to exploit stable atomic isotopes, will help spread the use of methods, such as nuclear magnetic resonance spectroscopy and mass ...
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Metabolism of selenite labelled with enriched stable isotope in the bloodstream
Journal of Chromatography B: Biomedical Sciences and Applications, 1997The metabolism of selenium (Se) in the bloodstream of rats was studied using HPLC-ICP-MS with an enriched Se stable isotope, and the results were used as Se-specific indicators for Se nutritional status. Concentration of endogenous Se in plasma depended on dietary Se, while changes in concentrations and distributions of exogenous Se revealed its ...
K T, Suzuki, M, Itoh
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Kinetic equivalence of stable-isotope-labeled and unlabeled phenytoin
Clinical Pharmacology and Therapeutics, 1981Stable isotope labeling (SIL) of a drug results in a higher molecular weight than that of the unlabeled drug. SIL tracer doses can be quantitated separately from unlabeled drug by gas chromatography-mass spectrometry (GC-MS) without exposing the patient to radiation. The higher molecular weight of SIL drug could cause a higher energy of activation for (
T R, Browne +4 more
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Progress in stable isotope labeled quantitative proteomics methods
Chinese Journal of Chromatography, 2013Quantitative proteomics is an important research field in post-genomics era. There are two strategies for proteome quantification: label-free methods and stable isotope labeling methods which have become the most important strategy for quantitative proteomics at present. In the past few years, a number of quantitative methods have been developed, which
Yuan, Zhou +3 more
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