Results 41 to 50 of about 185,787 (267)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Flat-tubular solid oxide fuel cells and stacks: a review

Journal of Asian Ceramic Societies, 2021
Solid oxide fuel cells (SOFCs) offer numerous advantages in terms of high efficiency and clean electrochemcial energy conversion devices. However, owing to high operation temperature, this technology is restricted to stationary applications and leads to ...
Muhammad Zubair Khan, Asim Iltaf, Hafiz Ahmad Ishfaq, Fahd Nawaz Khan, Waqas Hassan Tanveer, Rak-Hyun Song, Muhammad Taqi Mehran, Mohsin Saleem, Amjad Hussain, Zubair Masaud   +9 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Design and Analysis of a Novel Opposite Trapezoidal Flow Channel for Solid Oxide Electrolysis Cell Stack

Energies, 2022
High efficiency, raw material availability, and compatibility with downstream systems will enable the Solid Oxide Electrolysis Cell (SOEC) to play an important role in the future energy transition. However, the SOEC stack’s performance should be improved
Zhen Zhang, Chengzhi Guan, Leidong Xie, Jian-Qiang Wang   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Hilbert stack

Advances in Mathematics, 2014
Let π: X -> S be a morphism of algebraic stacks that is locally of finite presentation with affine stabilizers. We prove that there is an algebraic S-stack, the Hilbert stack, parameterizing proper algebraic stacks mapping quasi-finitely to X. This was previously unknown, even for a morphism of schemes.
Hall, Jack, Rydh, David
openaire   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

An Overview of WebAssembly for IoT: Background, Tools, State-of-the-Art, Challenges, and Future Directions

Future Internet, 2023
This paper explores the relationship between two emerging technologies, WebAssembly (Wasm) and the Internet of Things (IoT). It examines the complementary roles of these technologies and their impact on modern web applications.
Partha Pratim Ray
doaj   +1 more source