Results 51 to 60 of about 185,787 (267)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Numerical Analysis of Flow in U-Type Solid Oxide Fuel Cell Stacks

Energies
Numerical analysis of a U-type solid oxide fuel cell stack was performed using computational fluid dynamics to investigate the effects of stack capacities and fuel/air utilization rates on the internal flow uniformity.
Hao Yuan Yin, Kun Woo Yi, Young Jin Kim, Hyeon Jin Kim, Kyong Sik Yun, Ji Haeng Yu   +5 more
doaj   +1 more source

Scientific Opinion on application (EFSA‐GMO‐NL‐2012‐108) for the placing on the market of the herbicide‐tolerant genetically modified soybean MON 87708 × MON 89788 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto

EFSA Journal, 2015
Single events MON 87708 and MON 89788 were combined to produce the stack two‐event soybean MON 87708 × MON 89788. The EFSA GMO Panel previously assessed the two single events and did not identify safety concerns in the context of their scope. No new data
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Effect of Cell Size on the Performance and Temperature Distribution of Molten Carbonate Fuel Cells

Energies, 2020
Molten carbonate fuel cells (MCFCs) are high-operating-temperature fuel cells with high efficiency and fuel diversity. Electrochemical reactions in MCFCs are exothermic.
Jae-Hyeong Yu, Chang-Whan Lee
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

INVESTIGATION OF THE INFLUENCE OF INFORMATION SECURITY CELL STACK MATERIAL PARAMETERS ON ITS RELIABILITY

Измерение, мониторинг, управление, контроль, 2021
Background. Printed circuit boards of modern analog, digital and digital-analog electronic devices of medium complexity and higher have a base in the form of a stack-a set of layers for various purposes, which are subsequently pressed into a single ...
P.A. Maksimov, A.S. Ishkov, M.K. Markelov   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Hidden Abstract Stack Markov Models with Learning Process

Mathematics
We present hidden abstract stack Markov models (HASMMs) with their learning process. The HASMMs we offer carry the more expressive nature of probabilistic context-free grammars (PCFGs) while allowing faster parameter fitting of hidden Markov models (HMMs)
Mete Özbaltan
doaj   +1 more source

Digital Infrastructure, Liminality, and World-Making Via Asia| Gateways, Sieves and Domes: On the Infrastructural Topology of the Chinese Stack

International Journal of Communication, 2021
This article proposes a topological model capable of accounting for the scale and complexity of China’s digital infrastructure. Beginning with the troubled development of a submarine data cable between Los Angeles and Hong Kong, it identifies the ...
Gabriele de Seta
doaj