Results 191 to 200 of about 1,437,994 (264)

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Integration of stepped care for perinatal mood and anxiety disorders among women attending maternal and child health clinics in Kenya: Protocol for a cluster randomized controlled trial. [PDF]

PLoS One
Karume AK, Ngumbau N, Ongeri L, Neema A, Kaggiah A, Owaga D, Maina C, Ndambuki C, Wang Y, Pothan L, Rose A, Larsen A, Masyuko S, Richardson BA, Wagner AD, Bhat A, Ronen K, Kinuthia J.   +17 more
europepmc   +1 more source

Wide Temperature Zero Thermal Expansion in Al Matrix Composites with High Thermal Conductivity

Advanced Science, EarlyView.
Strain engineering strategy is implemented on the negative thermal expansion (NTE) phase Zn1.6Mg0.4P2O7 within composites, where Al matrix‐induced compressive strain drives uniform polyhedral and unit cell evolution, thereby enabling broad and consistent thermal compensation efficacy and obtaining good thermal performance.
Jinrui Qian, Feixiang Long, Yiqing Liu, Longlong Fan, Mingqing Liao, Qilong Gao, Hao Lu, Dexiang Gao, Le Kang, Yuzhu Song, Xiuzhu Han, Yue Sun, Naike Shi, Chang Zhou, Jun Chen   +14 more
wiley   +1 more source

'I've got a pupil who vapes every 20 minutes': exploration of the wider impact on schools of young people's use of new nicotine products in the UK. [PDF]

BMJ Open
MacGregor A, Hamid A, Shields J, Minty S, Morgan AJ, Zheng C, Shortt N, Pearce J, Ford A.   +8 more
europepmc   +1 more source

Structurally Complex Precipitates Enhance Strength‐Ductility Synergy in a Duplex Medium Entropy Alloy

Advanced Science, EarlyView.
Strong‐yet‐ductile precipitation‐hardening alloys require novel microstructural complexity of precipitates in particularly at cryogenic condition, to constantly impart strain hardening of hard‐and‐brittle precipitates. The present work creates innovative structurally complex precipitates assembled with dispersed nanocores and a chemical‐heterogeneity ...
Shaohua Gao, Yang Yang, Xiaoxuan Fan, Jinyu Zhang, Shuaiyang Liu, Jiao Li, Hui Wang, Wenli Song, Gang Liu, Jun Sun   +9 more
wiley   +1 more source

Exploring Knowledge and Awareness of Lewy Body Dementia Among Staff in Long-Term Care Facilities. [PDF]

J Multidiscip Healthc
Keane O, Fitzpatrick RL, Walsh S, Connelly JP, Leroi I.   +4 more
europepmc   +1 more source

Barriers and Facilitators to Caring for People Presenting With Suicidal Distress in Rural Emergency Departments: A Qualitative Study. [PDF]

Int J Ment Health Nurs
Modderman C, Veresova M, McAleer R, Hanson L, Hemming L, Maude P, Spelten E.   +6 more
europepmc   +1 more source

Facility staff perspectives on the implementation of Maternal and Perinatal Death Surveillance and Response in six health facilities in Kigoma, Tanzania. [PDF]

PLoS One
Huber-Krum S, Hartley S, Spencer P, Galioto L, Msuya A, Serbanescu F.   +5 more
europepmc   +1 more source