Results 121 to 130 of about 879,906 (340)

Towards a clinical staging for bipolar disorder: defining patient subtypes based on functional outcome.

, 2013
BACKGROUND: The functional outcome of Bipolar Disorder (BD) is highly variable. This variability has been attributed to multiple demographic, clinical and cognitive factors.
Ayuso-Mateos, José L, Frangou, Sophia, Harvey, Philip, Mar Bonnín, C, Papachristou, Efstathios, Ploubidis, George B, Reinares, María, Sánchez-Moreno, José, Torrent, Carla, Vieta, Eduard   +9 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Reliability of sentinel lymph node biopsy for staging melanoma [PDF]

, 2000
Liesbeth Jansen, Omgo E. Nieweg, J. L. Peterse, Cornelis A. Hoefnagel, Renato A. Valdés Olmos, B.B.R. Kroon   +5 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Italian Clinical Practice Guidelines on Cholangiocarcinoma – Part I: Classification, diagnosis and staging

, 2020
Domenico Alvaro, Cesare Hassan, Vincenzo Cardinale, Guido Carpino, Luca Fabris, Enrico Gringeri, Vincenza Granata, Massimiliano Mutignani, Helen Morement, Felice Giuliante, Alfredo Guglielmi, Lorenzo Ridola, Marco Marzioni, Gian Luca Grazi, Maria Guido, Emilio Di Giulio, Giuseppe Tonini, Francesco Pantano, Rosanna Venere, Maria Consiglia Bragazzi, Francesca Biancanello, Jessica Faccioli, Aurora Giannetti, Marcello Cintolo, Michela Di Giunta, Martina Gambato, Alberto Lasagni, Francesco Izzo, Antonio Avallone, Jesús M. Bañales, Massimo Rossi, Carlo Catalano, Andrea Laghi, Giulia d’Amati, Maria Grazia Mancino, Lorenzo Ridola   +35 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Book Review: Staging the French Revolution: Cultural Politics and the Paris Opera, 1789-1794 [PDF]

, 2013
Dr. Wayne Wentzel\u27s review of Mark Darlow, Staging the French Revolution: Cultural Politics and the Paris Opéra, 1789-1794. Oxford and New York: Oxford University Press, 2012. xi + 421 pp.
Wentzel, Wayne C.
core   +1 more source