Results 111 to 120 of about 359,491 (304)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Electron microscopy images of pSer9GSK3β labeling in cortical and subcortical areas.

, 2013
A) pSer9GSK3β labeling in a neuron in the piriform cortex. The labeling is located in the rough endoplasmic reticulum (outlined arrows), free ribosomes (stars) and the outer mitochondrial membrane (black arrow).
Gautam N. Bijur (364319), Miguel Melendez-Ferro (367517), Rosalinda C. Roberts (367518), Emma Perez-Costas (367514), Johanna C. Gandy (367515)   +4 more
core   +1 more source

Microwave-Assisted Tissue Preparation for Rapid Fixation, Decalcification, Antigen Retrieval, Cryosectioning, and Immunostaining

International Journal of Cell Biology, 2016
Microwave irradiation of tissue during fixation and subsequent histochemical staining procedures significantly reduces the time required for incubation in fixation and staining solutions.
Kazuo Katoh
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

CDV immunohistochemistry staining of haired skin and footpad from a CDV-positive raccoon.

, 2020
Immunohistochemical labeling with a monoclonal IgG primary antibody to CDV viral envelope protein antigen (fast-red staining) in haired skin (A and B) and non-haired footpad (C and D) from a CDV positive raccoon.
Ania Tomaszewicz Brown (8748339), Annika Posautz (2793820), Denise McAloose (335638), Chris Walzer (190487), Paul P. Calle (7507550), Robin Brennan (8748348), Tracie A. Seimon (7309979), Angelika Auer (8748342), Sally Slavinski (8748345)   +8 more
core   +1 more source

To explore the targeting of toluidine blue: low molecular dextran-40 to the lymphatic system and its effect assessment

Scientific Reports
To investigate the targeting effect of toluidine blue-dextran-40 (TB-Dex-40) on the head and neck lymphatic system. Thirty healthy adult New Zealand white rabbits were randomly divided into two groups: the experimental group (TB-Dex-40 group, n = 15) and
Fengtong Liu, Yanling Sui, Minghui Yang, Shengbiao Wan, Wei Li, Wei Shang, Jun Cui   +6 more
doaj   +1 more source

Receptor-Mediated SPION Labeling of CD4⁺ T Cells for Longitudinal MRI Tracking of Distribution Following Systemic Injection in Mouse

Nanomaterials
Tracking T cells in vivo using MRI is a major challenge due to the difficulty of labeling these non-phagocytic cells with a sufficient contrast agent to generate a detectable signal change.
Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin   +7 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

SPIONs-labeled hUCMSCs for in vitro safety analysis and in vivo tracking in scarred monkey uteri

Scientific Reports
Cesarean section has been increasingly used, stem cells have a potential to improve the repairing of scarred uteri, but its mechanism is still unclear. Cell labeling and tracking are becoming increasingly important in stem cell research.
Huiting Ma, Yingchun Wan, Xiuyin Shen, Xin Luo, Shuzhen Wu, Xiafen Lu, Fengying Chen, Weibin Liao, Qingjian Deng, Ting Chen, Xiaotie Chu, Zhengping Liu   +11 more
doaj   +1 more source